摘要
目的观察早期结膜下注射5-氟尿嘧啶(5-FU)对控制急性闭角型青光眼行小梁切除术患者前房炎性反应的作用。方法将36例(48只眼)青光眼患者施行小梁切除术联合白内障囊外摘除(ECCE)+人工晶体植入(IOL)术,随机分成A、B两组:A组(24只眼),术毕球旁注射地塞米松2.5 mg,同时立即球结膜下注射5-FU 5 mg,术后第1天应用0.1%地塞米松滴眼液及抗生素滴眼液点眼,视前房内纤维素渗出情况隔日注射5-FU 5 mg,总量不超过30 mg。B组(24只眼),术毕球旁注射地塞米松2.5 mg,术后第1天应用0.1%地塞米松滴眼液及抗生素滴眼液点眼;观察术后1、3、7 d及1个月的眼压、滤过泡、前房深度、纤维渗出完全吸收时间和最佳矫正视力恢复时间。结果两组患者术前、术后7 d及术后1个月的眼压差异无统计学意义。(2)术后前房纤维渗出吸收时间,A组和B组的平均时间分别为(5.2±3.4)d vs.(14.2±3.4)d,两组比较,有统计学意义(P<0.01)。恢复至最佳矫正视力的平均时间分别为(8.3±2.4)d vs.(14.3±4.2)d,两组比较,有显著统计学意义。结论术后早期应用5-FU能有效的减轻前房内纤维素样渗出,同时促进患者视力恢复。
Objective To observe the effect of early subconjunctival injection of 5-FU in anterior chamber on anti-inflammation in patients underwent acute angle-closure glaucoma surgery.Methods Thirty-six patients(48 eyes) with acute angle-closure glaucoma undergoing combined ECCE-trabeculectomy were divided into two groups.The patients in group A were given subconjunctival injection of 5-FU 5 mg and dexamethasone 2.5 mg at the end of operation,eye drops of 0.1% dexamethasone and antibiotics on the 1st postoperative d...
出处
《江苏医药》
CAS
CSCD
北大核心
2009年第2期179-181,共3页
Jiangsu Medical Journal
