摘要
动物机体组织的氧化紧张损伤和老化交联是糖尿病晚期并发症中神经病变、动脉粥样硬化、风湿性关节炎、肾病变、白内障等老化慢性疾病的共同特征 .对氧化紧张到底是糖尿病晚期并发症的初始原因还是糖尿病组织衰变的次级诱因提出了探讨 .结果表明 :糖尿病患者机体和血浆中的糖氧化产物及脂类过氧化物的增多表明病患者体内氧化紧张的加强 ;然而 ,它们中的某些产物与氧化紧张并不相关 ;此外 ,其它一些氧化紧张的直接指标 ,如氨基酸的氧化 ,在糖尿病患者的皮肤胶原中也并没有增多 .因此 ,对于糖尿病患者中蛋白质化学修饰的现象 ,用活性羰基的毒化超过其系统解毒能力的观点来解释更合适 .这种在氧化或非氧化反应中形成的不饱和羰基化合物在体内总是以相对恒定的浓度存在 ,因而在糖尿病中 。
Various biological-side reactions, such as oxidative stress and glycation resulting in damages to tissues are found to be common end stage of chronic diseases, such as diabetes, atherosclerosis, and rheumatoid arthritis. However, whether such reactions, as carbonyl stress has a primary role or a secondary effect of apoptotic tissue damage in diabetes is under vigorous debate. The increase in glycoxidation and lipoxidation products in plasma and tissue proteins suggests that oxidative stress is increased in diabetes related chronic diseases. However, some of these products, such as 3-deoxyglucosones to their lysine and arginine adducts, are formed independent of oxidation chemistry. Carbonyl products have been found to be increased without depending on an increase in oxidative stress. It has also been shown that the increased chemical modification of proteins in diabetes is the result of overload on metabolic pathways with a weakened detoxification of reactive carbonyl species. The carbonyl stress of tissue proteins in diabetes should thus be studies more seriously. The difference between oxidative and carbonyl stress is discussed also for future therapeutic applications.
出处
《生命科学研究》
CAS
CSCD
2001年第z1期73-77,共5页
Life Science Research
基金
国家自然科学基金项目 ( 30 0 70 874)
关键词
糖尿病晚期并发症
羰基毒害
氧化应激
糖基化终产物
diabetic complications
carbonyl stress
oxidative stress
advanced glycation end-products(AGEs)
