摘要
目的 研究肝癌多药耐药 (MDR)机制。 方法 采用阿霉素 +丝裂霉素通过药物间断 /持续接触诱导法诱导 SMMC 772 1细胞株建立一组多重人肝癌 MDR细胞模型 SMMC 772 1/ M细胞亚系。 结果 多重人肝癌MDR亚系 SMMC 772 1/ M的耐药涉及 mdr1 、MRP、L RP、Topo α和 GSTP1 基因。 结论 SMMC 772 1/ M亚株是目前肝癌
Objective\ To study multidrug resistance(MDR) mechanism of hepatocellular carcinoma(HCC).\ Methods\ By using ADM+MMC of chemotheraputic agents HCC cell lines\|SMMC 7721, a group of complex MDR cell sublines were successfully established.\ Results\ Observation on the model's drug resistance mechanism revealed that drug resistance in the complex\|MDR subline SMMC 7721/M was mediated by mdr\-1, MRP, LRP, TopoⅡα and GST\-\{P1\} genes collectively.\ Conclusion\ The established SMMC 7721/M subline was an optimal ...
出处
《福建医科大学学报》
2001年第S1期39-42,共4页
Journal of Fujian Medical University
