摘要
目的:研究收涩中药椿皮抑制血管生成及抗肿瘤生长的作用及机制。方法:采用小鼠移植肿瘤模型,研究椿皮对肿瘤生长的影响;应用免疫组织化学方法,检测肿瘤组织相关第八因子抗原(Ⅷ-RAg)和基质金属蛋白酶9(MMP-9)的表达,通过医用图像处理软件测定肿瘤组织的微血管密度(MVD)。结果:椿皮对小鼠皮下移植肉瘤有明显抑制作用(P<0.05);血管密度椿皮组明显低于空白和阳性对照组(P<0.05);椿皮相对于空白对照组MMP-9呈低表达(P<0.05)。结论:收涩中药椿皮对肿瘤血管生成有一定的抑制作用,可以抑制移植S180肉瘤的生长及MMP-9的表达。
Objective:To investigate the effect on angiogensis as well as tumor growth for the traditional Chinese medical astringent,such as,Cortex Ailanthi,and the mechanism of the effect.Method:A model of transplanting tumor in mice was used to study the effect of these medical herbs on tumor growth.The expression of Ⅷ-RAg and matrix metalloproteinase-9(MMP-9) in tumor tissue were examined with immunohistochemical method.The microvessel density(MVD) of the tumour tissue was also measured with the Image Pro Plus soft...
出处
《中国实验方剂学杂志》
CAS
2008年第8期48-50,共3页
Chinese Journal of Experimental Traditional Medical Formulae
