摘要
目的:比较小分子量壳聚糖及其衍生物羧甲基壳聚糖对口腔五种常见致病菌的体外抑菌作用。方法:用纸片药敏试验检测壳聚糖粘度5、(浓度2%pH6.5),羧甲基壳聚糖(MW-分子量1～2万,浓度2.0%1.5%1.0%0.5%)和羧甲基壳聚糖粘度30(浓度2.0%)对金黄色葡萄球菌,白色念珠菌,幽门螺杆菌,牙龈卟啉菌和变形链球菌的抑菌环情况,并测定以上浓度羧甲基壳聚糖MV1～2万和粘度30的抑菌率。结果:壳聚糖和羧甲基壳聚糖对5种致病因均有抑菌作用;但羧甲基壳聚糖只有接触性抑菌作用;2.0%浓度羧甲基壳聚糖的接触性抑菌作用最强,且小分子量优于中分子量;经高温处理的羧甲基壳聚糖抑菌作用稳定。结论:壳聚糖在pH6.5条件下对口腔五种常见致病菌的抑菌作用优于羧甲基壳聚糖;羧甲基壳聚糖只有接触性抑菌作用。
Objection:To study the antibacterial activities of low molecular weight chitosan and its derivative-CM-chitosans of low and middle molecular in vitro.Methods:The inhibitory effects of chitosan 5cps(2.0%pH 6.5)、CM-chitosans MV 1~2ten thousand(2.0% 1.5% 1.0% 0.5%)and CM-chitosans 30cps(2.0%)on Staphylococcus aureus,Candida albicans,Helicobacter pylori,Streptococcus mutans and Porphyomonas gingivalis in culture were measured.And the differences of their antibacterial activities under high temperature and after...
出处
《陕西医学杂志》
CAS
北大核心
2008年第7期809-811,共3页
Shaanxi Medical Journal
关键词
多糖类/治疗应用
抑制
化学性
微生物敏感性试验
口腔疾病
Polysaccharides/therapeutic use Depression
chemical Microbial sensitivity teste Mouth diseases
