期刊文献+

单克隆抗体类抗肿瘤药物的临床应用和进展 被引量:7

Clinical application and development of monoclonal antibody antineoplastic agents
下载PDF
导出
摘要 将化疗药物、放射性物质以及生物毒素等 与单克隆抗体偶联就得到单克隆类药物。由于抗原 抗体结合的特异性,这些偶联的药物被单克隆抗体 导向表达相应抗原的细胞并发挥抗肿瘤效应。单克 隆抗体类抗肿瘤药物有效地降低了传统肿瘤药物治 疗的不良反应,提高了治疗的精确性。 Monoclonal antibody agents can be obtained by coupling the chemotherapy agents, radioactive materials, biotoxin and monoclonal antibody. The coupling agents were directed by monoclonal antibody to express corresponding antigen and produced antineoplasm effect because of the specificity conjunction of the antigen and antibody. Monoclonal antibody antineoplastic agents can decrease the side effects of traditional medicine on tumor and improve the efficacy of treatment.
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 2005年第2期136-139,共4页 Chinese Journal of New Drugs and Clinical Remedies
关键词 抗体 单克隆 肿瘤治疗方案 抗肿瘤药 偶联 依决洛单抗 曲司珠单抗 利妥昔单抗 托西莫单抗 antibodies monoclonal antineoplastic protocols antineoplastic agents coupling edrecolomab trastuzumab rituximab tosithmomab
  • 相关文献

参考文献16

  • 1[1]KIRCHNER EM,GERHARDS R,VOIGTMANN R.Sequential immunochemotherapy and edrecolomab in the adjuvant therapy of breast cancer:reduction of 17-1A-positive disseminated tumour cells[J].Ann Oncol,2002,13(7):1044-1048. 被引量:1
  • 2[2]ARTEAGA CL.Trastuzumab,an appropriate first-line single-agent therapy for HER2-overexpressing metastatic breast cancer[J].Breast Cancer Res,2003,5(2):96-100. 被引量:1
  • 3[3]MONTSERRAT E.Rituximab in chronic lymphocytic leukemia[J].Semin Oncol,2003,30(1 Suppl 2):34-39. 被引量:1
  • 4[4]CZUCZMAN MS,GRILLO-LOPEZ AJ,WHITE CA,et al.Treatment of patients with low-grade B-cell lymphoma with the combination of chimeric anti-CD20 monoclonal antibody and CHOP chemotherapy[J].J Clin Oncol,1999,17(1):268-276. 被引量:1
  • 5[5]VOSE JM,LINK BK,GROSSBARD ML,et al.Phase II study of rituximab in combination with CHOP chemotherapy in patients with previously untreated,aggressive non-Hodgkin's lymphoma[J].J Clin Oncol,2001,19(2):389-397. 被引量:1
  • 6[6]SLAMON DJ,LEYLAND-JONES B,SHAK S,et al.Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that over expresses HER2[J].N Engl J Med,2001,344(11):783-792. 被引量:1
  • 7[7]PEGRAM MD,LOPEZ A,KONECNY G,et al.Trastuzumab and chemotherapeutics:drug interactions and synergies[J].Semin Oncol,2000,27(6 Suppl 11):21-25. 被引量:1
  • 8[8]SAFAVY A,BONNER JA,WAKSAL HW,et al.Synthesis and biological evaluation of paclitaxel-C225 conjugate as a model for targeted drug delivery[J].Bioconjug Chem,2003,14(2):302-310. 被引量:1
  • 9[9]HARWOOD SJ,GIBBONS LK,GOLDNER PJ,et al.Outpatient radioimmunotherapy with Bexxar.Closed,clean air reservoir minimizes personnel radiation exposure[J].Cancer,2002,94(4 Suppl):1358-1362. 被引量:1
  • 10[10]ROSENBLUM MG,VERCHRAEGEN CF,MURRAY JL,et al.Phase I study of 90Y-labeled B72.3 intraperitoneal administration in patients with ovarian cancer:effect of dose and EDTA coadministration on pharmacokinetics and toxicity[J].Clin Cancer Res,1999,5(5):953-961. 被引量:1

同被引文献89

引证文献7

二级引证文献38

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部