摘要
目的探讨环氧化酶-2(COX-2)抑制剂塞来昔布对膀胱癌裸鼠皮下移植瘤及移植瘤细胞凋亡的影响。方法6周龄BALB/c裸鼠8只,建立膀胱癌裸鼠皮下移植瘤动物模型,分为2组,实验组每kg食物添加1g塞来昔布,观察塞来昔布对裸鼠健康状况、体重变化及移植瘤变化的影响,并用TUNEL方法检测其对移植瘤细胞凋亡的影响。结果塞来昔布对裸鼠健康状况及体重变化无明显影响(P>0.05),对移植瘤的生长有抑制作用,肿瘤抑制率为83.7%(P<0.05),对移植瘤细胞的凋亡有促进作用(P<0.05)。结论塞来昔布可能通过促进肿瘤细胞凋亡等途径对膀胱肿瘤产生抑制作用,可能成为膀胱肿瘤化学预防及治疗的辅助手段。
Objective To investigate the effect of cyclooxygenase-2(COX-2) inhibitor celecoxib on bladder cancer xenografts in nude mice and apoptosis of tumor cells in the xenografts. Methods Models of bladder cancer xenograft in nude mice was used to observe the effect of celecoxib on the animals and the xenografts.TUNEL was used to assess apoptotic index of tumor cells in the xenografts. Results Celecoxib could effectively inhibit the growth of xenografts(P<0.05) with 83.7% of inhibition rate and induce apoptosis...
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2006年第S1期30-32,共3页
Chinese Journal of Urology
关键词
膀胱肿瘤
癌
环氧化酶-2
塞来昔布
凋亡
Bladder neoplasms
Carcinoma
Cyclooxygenase-2
Celecoxib
Apoptosis
