摘要
应用micro-CT获得腰椎松质骨微结构的三维参数,分析卵巢切除术与雌二醇干预对大鼠松质骨微结构及整体骨生物力学性能的作用,初步讨论松质骨微结构的改变对生物力学性能的影响。6月龄未交配雌性SD大鼠30只,随机分成3组(每组10只):假手术对照组(Sham)、去卵巢组(OVX)和去卵巢+补充雌二醇组(EBT)。术后相同条件饲养5个月,取第3腰椎进行生物力学压缩试验,第4腰椎行micro-CT扫描。结果表明,与相应的Sham组比较,OVX组的BV/TV、Tb.N均明显下降,Tb.Sp和SMI明显增高。EBT组的BV/TV、Tb.N和Tb.Th均大于OVX组,Tb.Th和SMI明显小于OVX组。骨力学性能检测显示OVX组腰椎松质骨E、Fmax和σmax均明显降低,而EBT组上述骨生物力学参数均明显改善。通过micro-CT获得的骨微结构参数并结合骨力学性能检测能为合理评价骨质疏松及抗骨质疏松药物药效研究提供较好的实验依据。
This study was aimed at observing the effects of ovariectomy and estradiol on the microarchitecture of cancellous bone and exploring the influence of microarchitectural change on the biomechanical properties.Thirty 6-month-old unmated female SD rats were randonmly divided into 3 groups(10 rat each): sham-operated control group (Sham), ovariectomized group (OVX)and Estradiol Benzoate treated group(EBT). All rats were housed in standard environmental conditions. Five months after operation, the rats were sacr...
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2008年第3期626-631,636,共7页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(30770534
30270359)
