摘要
应激是机体对伤害性环境改变作出的反应,常引起动物产生焦虑样行为.研究表明,应激、焦虑与促肾上腺皮质激素释放因子(CRF)及其受体有关.本文综述了CRF及其受体在应激和焦虑样行为反应中的作用的最新研究进展,为克服焦虑情绪及其由此产生的心理疾病提供理论依据.
Anxiety-like behaviors can be triggered by stress and exogenous CRF. This process seems to be modulated by CRF receptor 1. Evidences taken from CRF receptor 1 transgenic knockout mice, CRF receptor 1 antisense oligonucleotides work, as well as receptor 1 selective antagonist studies all suggested this conclusion. In contrast, fewer evidences were obtained from CRF receptor 2 studies. The role of CRF receptor 2 has long been related with animal behaviors such as feeding and reproduction, but according to recent findings, CRF receptor 2 may also take part in mediating anxiety-like behaviors.
出处
《浙江大学学报（工学版）》
EI
CAS
CSCD
北大核心
2004年第3期373-376,共4页
Journal of Zhejiang University：Engineering Science
