摘要
目的 探讨术前不同治疗方法对宫颈癌的近期疗效.方法 选择本院2002年1月至2006年2月收的42例ⅠB2～ⅡB期宫颈癌,对术前同步放、化疗组即新辅助化疗联合腔内后装放疗组15例,新辅助化疗组11例,腔内后装放疗组16例患者进行分析.结果 ①术前同步放、化疗组与新辅助化疗组、腔内后装放疗组对比,临床总有效率为75.0%.各组总有效率比较P＞0.05,无显著性差异.手术切除率100%;②宫颈癌患者经各组治疗后肿瘤直径较治疗前相比有不同程度的缩小,有显著性差异,P＜0.01;③新辅助化疗及术前同步放、化疗可减少术后盆腔淋巴结转移的阳性率及宫旁血管癌栓的发生率,各组盆腔淋巴结转移的阳性率比较,X2=1.36,P＞0.05,无显著性差异.结论 术前同步放、化疗可提高宫颈癌的近期疗效,成为治疗该病的一种新手段,具有重要的临床意义.
Objective To investigate short-term therapeutic effect of different treatment for patients with stage ⅠB2~ⅡB cervical carcinoma.Methods Totally,42 women with primary bulky cervical carcinoma in stage ⅠB2~ⅡB were treated with neoadjuvent chemotherapy alone(n=11) and intracavitary afterloading radiotherapy alone(n=16) and combination of neoadjuvent chemotherapy with intracavitary afterloading radiotherapy(preoperative synchronous chemo-radiotherapy)(n=15) from January 2002 to February 2006 in Jiangyin Municipal People's Hospital.Results Overall effective rate of preoperative synchronous chemo-radiotherapy was 75.0%.Between the neoadjuvent chemotherapy alone group and intracavitary afterloading radiotherapy alone group,there were no significant differences in overall effective rate(P>0.05).The rate of cervicectomy(trachelectomy) after chemo-radiotherapy was 100%.The primary tumor sizes of these patients received different therapies were significantly decreased at varied extent and the difference was significant(P<0.01).The incidences of positive pelvic lymph node metastasis and parametrial intravascular cancer embolism were reduced after either neoadjuvent chemotherapy or preoperative synchronous chemo-radiotherapy.Conclusion Preoperative synchronous chemo-radiotherapy can improve the short-term therapeutic effect of cervical carcinoma,so it is a new effective treatment for stage ⅠB2~ⅡB cervical carcinoma.It shows promising prospect in clinical application.
出处
《中国妇幼健康研究》
2007年第5期450-451,共2页
Chinese Journal of Woman and Child Health Research
关键词
新辅助化疗
宫颈肿瘤
手术治疗
放射治疗
neoadjuvant chemotherapy
cervical neoplasm
surgical treatment
radiotherapy
