摘要
在目前的动物学研究和临床医学研究中已经得以证实,间充质干细胞(MSC)在软骨损伤后修复的过程中具有一定程度的有效性。研究人员过去普遍认为MSC的治疗功效主要是源于其所具备的特有软骨分化潜能,而现如今的大量研究认为其治疗的功效主要来源于其旁分泌过程,特别是外泌体在其中的参与具有十分重要的作用。本文探究MSC的外泌体在通过免疫调节与激发再生潜能的方式修复软骨损伤过程中的可能机制。
Current animal and clinical studies have demonstrated the effectiveness of mesenchymal stem cells(MSC)in repairing cartilage damage.Previous researchers believe that the therapeutic effect of MSC is mainly based on the chondrogenic differentiation potential of MSC.Now more and more studies have attributed the therapeutic effect to paracrine,especially the role of exosomes.This review aimed to investigate the potential mechanism of mesenchymal stem cell(MSC)exosomes in repair of cartilage damage through immune regulation and regeneration potential.
作者
姜博庸
韩长旭
Jiang Boyong;Han Changxu(Department of Pediatric Orthopedics,the Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010030,China;Department of Sports Medicine,the Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010030,China)
出处
《中华关节外科杂志（电子版）》
CAS
CSCD
2023年第1期44-51,共8页
Chinese Journal of Joint Surgery(Electronic Edition)
基金
内蒙古自治区自然基金资助项目(2017MS0851,2017MS0815)
关键词
间质干细胞
外泌体
软骨
关节炎
综述
Mesenchymal stem cells
Exosomes
Cartilage
Arthritis
Review
