摘要
干细胞的成骨分化需要转录因子、信号通路和生物学信号的紧密协调。这种交互网络的失调会影响干细胞和成骨细胞的增殖和凋亡,从而破坏骨代谢和稳态。lncRNAs广泛参与干细胞的成骨分化过程,从而在骨关节炎、骨肿瘤等骨疾病的发生、发展和进展中发挥重要作用。长链非编码RNA HOX转录反义RNA(HOX transcript antisense RNA,HOTAIR)调节干细胞的成骨分化,并在骨形成和相关疾病的发展中起重要的中介作用。现就lncRNA HOTAIR在成骨分化及骨病中的具体作用和机制的相关研究作一综述,以期为未来骨与关节疾病的防治提供新的思路。
Osteogenic differentiation of stem cells requires the close coordination of transcription factors,signal pathways and biological signals.The disorder of this interactive network will affect the proliferation and apoptosis of stem cells and osteoblasts,thereby destroying bone metabolism and homeostasis.In recent years,studies have shown that lncRNAs are widely involved in the osteogenic differentiation process of stem cells,thereby playing an important role in the occurrence,development and progression of bone diseases such as osteoarthritis and bone tumors.Long non-coding RNA HOX transcript antisense RNA(lncRNA HOTAIR)regulates the osteogenic differentiation of stem cells,and plays an important mediating role in the development of bone formation and related diseases.The specific role and mechanism of lncRNA HOTAIR in osteogenic differentiation and bone diseases are reviewed,in order to provide new ideas for the prevention and treatment of bone and joint diseases in the future.
作者
徐昌超
孙红
蓝奉军
吴鸿斌
杨华
XU Changchao;SUN Hong;LAN Fengjun;WU Hongbin;YANG Hua(Department of Clinical Medicine,Guizhou Medical University,Guiyang,Guizhou 550004,China;Department of Orthopedics,Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou 550004,China;Department of Orthopedics,Jinjiang People´s Hospital,Jinjiang,Fujian 362200,China)
出处
《安徽医药》
CAS
2023年第7期1283-1288,共6页
Anhui Medical and Pharmaceutical Journal
基金
贵州省卫生健康委科学技术基金(gzwjkj2020-1-120)
贵州省基础研究计划(黔科合基础-ZK[2021]一般391)。
关键词
RNA
长链非编码
肌骨骼疾病
骨疾病
间质干细胞
骨生成
HOX转录反义RNA
骨与关节疾病
分子机制
综述
RNA,long noncoding
Musculoskeletal diseases
Bone diseases
Mesenchymal stem cells
Osteogenesis
HOX transcript antisense RNA
Bone and joint diseases
Molecular mechanisms
Review
