摘要
目的探究中性粒细胞和高密度脂蛋白比值(NHR)与下肢动脉疾病(LEAD)的相关性。方法选择北京大学首钢医院血管医学科2016年1月至2017年10月的中老年住院患者644人,根据肱踝指数将中老年患者分为非下肢动脉疾病组(非LEAD)578例和下肢动脉疾病组(LEAD)66例。基线收集的数据将包括参与者的人口统计数据,生活方式,疾病史,实验室血常规和生化。采用Pearson相关性分析法分析中性粒细胞和高密度脂蛋白比值与下肢动脉疾病的相关性,进一步制作ROC曲线以明确NHR对LEAD的预测价值,采用多因素Logistic回归分析下肢动脉疾病患者的影响因素,采用单因素方差分析比较NHR不同水平组的血管功能。结果非LEAD组与LEAD组年龄、性别、吸烟史、饮酒史,高血压、糖尿病、高尿酸血症、用药史,MON、TC、TG、AST、ALT、TBIL、DBIL、Cr、hsCRP、HCY比较,差异无统计学意义(P>0.05)。LEAD组WBC、NEU高于非LEAD组,非LEAD组LYM、LDL、HDL高于LEAD组(P<0.05或P<0.01)。Pearson相关分析结果显示,本研究中老年人群中NHR与ABI呈负相关(P<0.01)。多因素Logistic回归结果显示,NHR为LEAD独立危险因素(P<0.05)。单因素方差分析结果提示,NHR不同水平组的血管功能,即ABI、CAVI、CF-PWV均有统计学差异(P<0.05),且NHR高水平组ABI小于NHR低水平组,而CAVI和CF-PWV在NHR高水平组中较高。结论中老年人群NHR增高与LEAD相关,对预测中老年人群患LEAD具有一定价值。
Objective To investigate the correlation between the neutrophil/high-density lipoprotein ratio(NHR)and lower extremity atherosclerotic disease(LEAD)in middle-aged and elderly people.Methods A total of 644 middle-aged and elderly inpatients treated at the Department of Vascular Medicine,Peking University Shougang Hospital from January 2016 to October 2017 were selected.According to brachial and ankle index,the patients were divided into either a non-LEAD group(n=578)or an LEAD group(n=66).Data collected at baseline included participants'demographic data,lifestyle,disease history,routine blood examination,and biochemistry examination.Pearson correlation analysis was used to analyze the correlation between NHR and LEAD.ROC curves were plotted to determine the predictive performance of NHR for LEAD.Multivariate Logistic regression was used to analyze the influencing factors of LEAD.One-way analysis of variance was used to compare the vascular function of different NHR groups.Results There was no significant difference in age,sex,smoking history,drinking history,hypertension,diabetes,hyperuricemia,medication history,MON,TC,TG,AST,ALT,TBIL,DBIL,Cr,hsCRP,or HCY between the non-LEAD group and the LEAD group(P>0.05).WBC and NEU in the LEAD group were significantly higher than those in the non-LEAD group,while LYM,LDL,and HDL in the non-LEAD group were significantly higher than those in the LEAD group(P<0.05 or P<0.01).Pearson correlation analysis showed that there was a negative correlation between NHR and ABI in the middle-aged and elderly population(P<0.01).Multivariate Logistic regression showed that NHR was an independent risk factor for LEAD(P<0.05).One-way ANOVA showed that there were significant differences in ABI,CAVI,and CF-PWV among the groups with different levels of NHR(P<0.05).ABI in the high NHR group was smaller than that in the low NHR group,while CAVI and CF-PWV were higher in the high NHR group.Conclusion The increase of NHR in middle-aged and elderly people is associated with LEAD,which has important va
作者
陈捷
白易
刘金波
刘欢
赵娜
赵红薇
王宏宇
Chen Jie;Bai Yi;Liu Jinbo;Liu Huan;Zhao Na;Zhao Hongwei;Wang Hongyu(Department of Vascular Medicine,Peking University Shougang Hospital,Beijing 100144,China;Department of Epidemiology and Health Statistics,School of Public Health,Peking University,Beijing 100191,China;Vascular Health Research Center of Peking University Health Science Center(VHRC-PKUHSC),Beijing 100144,China;Key Laboratory of Molecular Cardiovascular Sciences(Peking University),Ministry of Education,Beijing 100144,China)
出处
《中华临床医师杂志（电子版）》
CAS
北大核心
2023年第4期402-408,共7页
Chinese Journal of Clinicians(Electronic Edition)
基金
2014年度临床重点项目(2014-Yuan-LC-02)
2019年度临床重点项目(2019-Yuan-LC-01)
2020年首都卫生发展科研专项(首发2020-2-6042)
北京大学首钢医院科研与发展基金-中国数字心脏和血管健康研究暨中国新首钢队列研究(2022-2024)
基于北京血管健康分级标准的智慧化数字心脏和血管健康管理系统应用价值研究(SGYYZ202105)
关键词
中性粒细胞和高密度脂蛋白比值
下肢动脉疾病
相关性分析
Neutrophil/high density lipoprotein ratio
Lower extremity arterial disease
Correlation analysis
