摘要
目的探讨甲状腺细针穿刺细胞蜡块技术对提高病理诊断准确性的意义。方法随机选择河北省人民医院113例术前可疑且术后病理证实为甲状腺乳头状癌患者,手术前行细针穿刺后并进行了常规细胞学涂片和制作细胞蜡块。两种技术方法制作的涂片/切片进行满意度评价,评价两种方法的在病理诊断中的准确性。结果细胞蜡块法制作切片细胞排列结构完整,细胞核和细胞质结构清晰,不受红细胞影响,不满意度为0.9%(1/113),常规涂片组不满意度为8.8%(10/113),差异有统计学意义(P<0.05)。甲状腺乳头状癌诊断正确率方面,细胞蜡块法阳性率(110/113,97.3%)比常规涂片法阳性率(100/113,88.5%)高,差异有统计学意义(P<0.05)。结论对比甲状腺穿刺常规细胞涂片,细胞蜡块的满意度更高、诊断正确率更高;此外细胞蜡块还可以做免疫组织化学染色,解决疑难诊断问题。
Objective To explore the value of cell block technique in thyroid fine needle aspiration to improve the accuracy of pathological diagnosis of thyroid diseases.Methods One hundred and thirteen cases of papillary thyroid carcinoma from Hebei General Hospital were randomly selected,and routine cytological smears and cell embedding were performed after fine-needle aspiration.The diagnostic results were confirmed by postoperative pathological results.Results There was a statistically significant difference in the degree of dissatisfaction between the cell block group(1/113,0.9%)and the conventional smear group(10/113,8.8%).In terms of the diagnostic accuracy for papillary thyroid carcinoma,the positive rate in the cell block group(110/113,97.3%)was significantly higher than that of the conventional smear group(100/113,88.5%;P<0.05).Conclusion Compared with conventional cell smear,cell block technique has a higher degree of satisfaction and higher diagnostic accuracy.In addition,cell blocks can also be immunohistochemically stained to solve difficult diagnostic problems.
作者
杜倩
张曼
李丽
马晓丽
Du Qian;Zhang Man;Li Li;Ma XiaoLi(Department of Pathology,Hebei General Hospital,Shijiazhuang 050000,China;Department of Operating Room,Hebei General Hospital,Shijiazhuang 050000,China;Department of Ultrasound,Hebei General Hospital,Shijiazhuang 050000,China)
出处
《中华临床医师杂志（电子版）》
CAS
北大核心
2023年第10期1071-1074,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
河北省卫健委青年科技课题(20190403)
关键词
细胞蜡块
细胞涂片
细针穿刺
甲状腺乳头状癌
Cell block
Cell smear
Fine needle aspiration
Papillary thyroid carcinoma
