摘要
目的探讨腹主动脉钙化-8(AAC-8)评分系统对药物涂层球囊(DCB)扩张成形术后下肢动脉再狭窄或闭塞的预测作用。方法回顾性收集2018年9月至2022年6月南京大学医学院附属鼓楼医院因下肢动脉硬化闭塞症行DCB扩张成形术的62例患者的临床资料,其中男37例,女25例,年龄(73.9±11.3)岁。根据DCB扩张成形术后下肢动脉情况将患者分为两组:复发组(n=26)和通畅组(n=36)。采用logistic回归分析DCB扩张成形术后下肢动脉再狭窄或闭塞的相关因素。采用受试者工作特征(ROC)曲线分析AAC-8评分对DCB扩张成形术后下肢动脉再狭窄或闭塞的预测价值。结果通畅组术后随访时间[M(Q_(1),Q_(3))]为16.30(10.97,24.10)个月,复发组术后随访时间为9.03(6.98,15.31)个月。多因素logistic回归分析结果显示,AAC-8评分升高(OR=1.388,95%CI:1.067~1.806,P=0.015)是DCB扩张成形术后下肢动脉再狭窄或闭塞的相关因素。ROC曲线分析结果显示,AAC-8评分预测DCB扩张成形术后下肢动脉再狭窄或闭塞的曲线下面积(AUC)为0.687(95%CI:0.550~0.824,P=0.013),cut-off值为5.5分,灵敏度为65.4%,特异度为69.5%。结论AAC-8评分升高是DCB扩张成形术后下肢动脉再狭窄或闭塞的相关因素。cut-off值为5.5分时,其预测DCB扩张成形术后下肢动脉再狭窄或闭塞的灵敏度为65.4%,特异度为69.5%。
Objective To investigate the role of the Abdominal Aortic Calcification-8(AAC-8)scoring system in predicting restenosis or occlusion of lower extremity arteries after dilatation and angioplasty with drug-coated balloon(DCB).Methods In this retrospective study,62 patients who underwent dilatation and angioplasty with DCB for lower limb atherosclerotic obliterans(ASO)were enrolled from September 2018 to June 2022 in Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School.Among them who aged(73.9±11.3)years,37 were males and 25 were females.Patients were divided into two groups according to the condition of the lower extremity arteries after dilatation and angioplasty with DCB:recurrence group(n=26)and patency group(n=36).Logistic regression was used to analyze the factors associated with restenosis or occlusion of lower extremity arteries after dilatation and angioplasty with DCB.The predictive value of the AAC-8 score for restenosis or occlusion of the lower extremity arteries after dilatation and angioplasty with DCB was analyzed using the receiver operating characteristic curves(ROC curves).Results The postoperative follow-up was 16.30(10.97,24.10)months in the patency group and 9.03(6.98,15.31)months in the recurrence group.The results of multifactorial logistic regression analysis showed that an elevated AAC-8 score(OR=1.388,95%CI:1.067-1.806,P=0.015)was an associated factor of restenosis or occlusion of the lower extremity arteries after dilatation and angioplasty with DCB.The ROC curve analysis showed that the area under the curve(AUC)of the AAC-8 score for predicting restenosis or occlusion of the lower extremity arteries after dilatation and angioplasty with DCB was 0.687(95%CI:0.550-0.824,P=0.013),with a cut-off value of 5.5 points,a sensitivity of 65.4%and a specificity of 69.5%.Conclusions Elevated AAC-8 score is associated with restenosis or occlusion of the lower extremity arteries after dilatation and angioplasty with DCB.When the cut-off value is 5.5,the AAC-8 score predicts res
作者
蔡晶
张振希
乔彤
李晓强
王炜
Cai Jing;Zhang Zhenxi;Qiao Tong;Li Xiaoqiang;Wang Wei(Department of Vascular Surgery,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2024年第5期332-336,共5页
National Medical Journal of China
基金
国家自然科学基金(818870348、82200543)
江苏省卫生健康委医学科研项目(ZD2021056)
关键词
动脉硬化
闭塞性
腹主动脉钙化积分
药物涂层球囊
预测
Arteriosclerosis obliterans
Abdominal aortic calcification integral
Drug-coated balloon
Forecasting
