摘要
Objective: To study the correlation of maternal - placental circulation ultrasound parameters with placental hypoxia and oxidative stress in patients with preeclampsia. Methods: Patients with preeclampsia who gave birth in Shandong jiaotong hospital between March 2015 and February 2017 were select as the PE group of the study, and the healthy pregnant women who gave birth in the hospital during the same period were selected as the control group of the study. Color Doppler ultrasonography was done in the 23-26 weeks of pregnancy to determine the uterine spiral artery PI, RI and S/D levels;after delivery, the placenta was collected to determine the expression of hypoxia-induced apoptosis indexes, cell invasion molecules and oxidative stress molecules. Results: Uterine spiral artery PI, RI and S/D levels of PE group were significantly higher than those of control group;TXNIP, NLRP3, ASC, Caspase-1, Nrf-2, HO-1 and NQO-1 mRNA expression in placenta tissue of PE group were significantly higher than those of control group and positively correlated with uterine spiral artery PI, RI and S/D levels while CatL, CatB, uPA and LAMA4 mRNA expression were significantly lower than those of control group and negatively correlated with uterine spiral artery PI, RI and S/D levels. Conclusion: The increase of maternal - placental circulation blood resistance in patients with preeclampsia will result in the placental hypoxia, and aggravate the apoptosis and oxidative stress.
基金
Youth Project of National Natural Science Foundation of China NO:81402153.
