摘要
目的探索TACE序贯联合经皮射频消融(RFA)治疗原发性肝癌临床效果.方法选取2015年12月至2016年12月于本单位收治的114例病人(原发性肝癌)为观察对象,采用数字表法将所有观察对象随机单盲分成:对照组57例单纯应用肝动脉化疗栓塞术(TACE)治疗,观察组57例行TACE序贯联合经皮射频消融(RFA)治疗.术后均随访2年,比较两组患者治疗后的近期疗效、生存率及甲胎蛋白(AFP)下降情况.结果观察组肿瘤完全缓解率为12.28%、部分缓解率为66.66%、稳定率为17.54%,均明显高于对照组.观察组1年、2年生存率分别为81.80%、68.42%,对照组1年、2年生存率分别为75.43%、50.87%,两组差异有统计学意义(P<0.05),观察组甲胎蛋白下降率为78.94%对照组下降率为49.12%血清AFP下降率组间比较有统计学差异<0.05.结论TACE联合RFA治疗能有效地控制肿瘤的生长,可明显延长患者的生存期.
Objective To explore the clinical effect of TACE combined with percutaneous radiofrequency ablation(RFA)in the treatment of primary liver cancer.Method To choose between December 2015 and December 2016 in this unit were(primary liver cancer)of 114 cases of patients as observation object,using digital table method random single blind into all the observation object:57 cases were simple application of the hepatic artery chemoembolization with conventional therapy,observation group 57 routine sequential combined with conventional percutaneous radiofrequency ablation(RFA)therapy.All patients were followed up for 2 years after surgery,and the short-term efficacy,survival rate and the decrease of alpha-fetoprotein(AFP)after treatment were compared between the two groups.Results the tumor complete response rate was 12.28%,partial response rate was 66.66%and stability rate was 17.54%in the observation group,which were significantly higher than the control group.The 1-year and 2-year survival rates of the observation group were 81.80%and 68.42%,respectively,and the 1-year and 2-year survival rates of the control group were 75.43%and 50.87%,respectively.There were statistically significant differences between the two groups(P<0.05).Conclusion TACE combined with RFA can effectively control the growth of tumor and prolong the survival of patients.
作者
李本科
LI Ben-ke(Dalian Sixth People’s Hospital,Dalian 116031,China)
出处
《肝胆外科杂志》
2020年第2期129-132,共4页
Journal of Hepatobiliary Surgery
关键词
肝动脉化疗栓塞
经皮射频消融术
近期疗效
生存率
甲胎蛋白
hepatic artery chemoembolization
percutaneous radiofrequency ablation
short-term efficacy
survival rate
AFP
