摘要
目的探究含利福霉素钠注射液方案在肺结核患者中的应用效果。方法选取贵州省黔南布依族苗族自治州人民医院2022年7—12月收治的84例肺结核患者为研究对象,按照随机数字表法分为对照组与研究组,各42例。对照组采用常规治疗方案,研究组采用含利福霉素钠注射液方案。对比两组痰菌转阴情况、病灶吸收情况、空洞闭合情况、生活质量、日常生活活动能力以及不良反应。结果研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。研究组治疗后痰菌转阴率、病灶吸收率和空洞闭合率均高于对照组,组间差异有统计学意义(P<0.05)。研究组治疗后健康调查简表、日常生活活动能力量表评分分别为(71.32±10.31)分、(62.64±4.58)分,均高于对照组的(65.34±7.14)分、(55.68±3.62)分,组间差异有统计学意义(P<0.05)。研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论肺结核患者采用含利福霉素钠方案治疗,可有效缓解临床症状,有利于改善生活质量和日常生活活动能力,且用药安全可靠,值得临床推广应用。
Objective To explore the application effect of regimen containing rifamycin sodium injection in patients with pulmonary tuberculosis.Methods 84 patients with pulmonary tuberculosis admitted to the People's Hospital of Qiannan Buyi and Miao Autonomous Prefecture of Guizhou Province from July to December 2022 were selected as the research objects.According to the random number table method,they were divided into a control group and a study group,with 42 cases in each group.The control group received conventional treatment regimen,and the study group received regimen containing rifamycin sodium injection.Sputum bacteria negative conversion,focus absorption,cavity closure,quality of life,ability of daily living activities and adverse reactions were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).The sputum bacteria negative conversion rate,focus absorption rate and cavity closure rate of the study group were higher than those of the control group after treatment,and the differences between the groups were statistically significant(P<0.05).After treatment,the scores of the MOS item short from health survey and activity of daily living of the study groups were(71.32±10.31)points and(62.64±4.58)points,respectively,which were higher than(65.34±7.14)points and(55.68±3.62)points of the control group,and the differences between the groups were statistically significant(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The treatment of pulmonary tuberculosis patients with regimen containing rifamycin sodium injection can effectively relieve clinical symptoms,improve the quality of life and activities of life,and the drug is safe and reliable,worthy of clinical promotion and application.
作者
范贵红
陈小锰
陆睿
FAN Guihong;CHEN Xiaomeng;LU Rui(Department of Infection,People's Hospital of Qiannan Buyi and Miao Autonomous Prefecture,Guizhou Province,Qiannan Guizhou,558000,China)
出处
《反射疗法与康复医学》
2023年第11期170-173,共4页
Reflexology And Rehabilitation Medicine
关键词
肺结核
利福霉素钠
痰菌转阴率
病灶吸收
生活质量
不良反应
Pulmonary tuberculosis
Rifamycin sodium
Negative conversion rate of sputum bacteria
Focus absorption
Quality of life
Adverse reaction
