摘要
目的分析黄葵胶囊联合恩格列净对糖尿病肾病患者尿微量蛋白和炎症反应的影响。方法选择该院2020年6月—2023年4月收治的86例糖尿病肾病患者为研究对象,按电脑随机数字表法将其分为对照组与观察组。对照组(n=43)采用恩格列净辅助治疗,观察组(n=43)在对照组基础上联合黄葵胶囊治疗。比较两组患者治疗前后的临床疗效、肾功能、尿蛋白和炎症介质水平。结果观察组治疗总有效率为95.35%,高于对照组的79.07%,差异有统计学意义(P<0.05)。治疗前,两组24 h尿总量蛋白(UTP)和尿微量蛋白(U-mALB)水平比较,组间差异无统计学意义(P>0.05);治疗后,观察组UTP和U-mALB水平分别为(2.54±0.42)g、(752.41±60.55)mg,均低于对照组的(2.81±0.46)g、(780.13±60.63)mg,组间差异有统计学意义(P<0.05)。治疗前,两组血肌酐(SCR)、血尿素氮(BUN)和血清内转化生长因子-β_(1)(TGF-β_(1))水平比较,组间差异无统计学意义(P>0.05);治疗后,观察组SCR、BUN和TGF-β_(1)水平分别为(144.91±14.26)μmol/L、(7.19±1.55)mmol/L和(95.11±1.20)ng/L,均低于对照组的(165.57±20.74)μmol/L、(9.26±1.73)mmol/L和(112.96±3.08)ng/L,组间差异有统计学意义(P<0.05)。治疗前,两组C反应蛋白(CRP)和白细胞介素-6(IL-6)水平比较,组间差异无统计学意义(P>0.05);治疗后,观察组CRP与IL-6水平分别为(10.34±0.19)mg/L,(12.11±0.20)pg/mL,均低于对照组的(18.21±0.09)mg/L,(19.96±0.23)pg/mL,组间差异有统计学意义(P<0.05)。结论黄葵胶囊联合恩格列净治疗糖尿病肾病效果较好,能够减轻患者肾脏炎症,缓解蛋白尿,有助于提高其肾功能表现,临床实用性和安全性较高。
Objective To analyze the effects of Huangkui capsule combined with Englipzin on urinary microprotein and inflammation in diabetic nephropathy patients.Methods 86 diabetic nephropathy patients admitted to the hospital from June 2020 to April 2023 were selected as the study objects,and were divided into a control group and an observation group according to computer random number table method.The control group(n=43)was treated with the adjuvant therapy of englaglizin,and the observation group(n=43)was treated with the combination of yellow sunflower capsule on the basis of the control group.The clinical efficacy,renal function,urinary protein and inflammatory mediators of the two groups were compared before and after treatment.Results The total effective rate of the observation group was 95.35%,higher than 79.07%of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in 24 h urinary total protein(UTP)and urinary microprotein(UM)levels between the two groups(P>0.05);after treatment,UTP and UM levels in the observation group were(2.54±0.42)g and(752.41±60.55)mg,respectively,which were lower than(2.81±0.46)g and(780.13±60.63)mg in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in serum creatinine(SCR),blood urea nitrogen(BUN)and serum transforming growth factor-β_(1)(TGF-β_(1))levels between two groups(P>0.05);after treatment,the levels of SCR,BUN and TGF-β_(1) in observation group were(144.91±14.26)μmol/L,(7.19±1.55)mmol/L and(95.11±1.20)ng/L,respectively,which were lower than(165.57±20.74)μmol/L,(9.26±1.73)mmol/L and(112.96±3.08)ng/L in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in C-reactive protein(CRP)and interleukin-6(IL-6)levels between the two groups(P>0.05);after treatment,the levels of CRP and IL-6 in the observation group were(10.34±0.19)mg/L and(12.
作者
孙莹
SUN Ying(Department of Nephrology,Mengyin County People's Hospital,Linyi Shandong,276200,China)
出处
《反射疗法与康复医学》
2023年第18期164-167,共4页
Reflexology And Rehabilitation Medicine
关键词
糖尿病肾病
黄葵胶囊
恩格列净
尿微量蛋白
炎症反应
肾功能
Diabetic nephropathy
Yellow sunflower capsule
Englizin
Urinary microprotein
Inflammatory response
Renal function
