摘要
目的研究非小细胞肺癌表皮生长因子受体(EGFR)基因外显子突变与其临床病理特征的关系.方法以黑龙江省佳木斯市中心医院检验科接诊的非小细胞肺癌患者100例为研究对象,研究时间为2019年3月-2020年3月,获取肿瘤细胞,制作石蜡细胞块,取得基因检测标本,分析EGFR突变情况、临床病例特征关系.结果100例患者中,43例发生EGFR基因外显子突变(43.00%).不同性别、吸烟、腺癌患者的EGFR基因外显子突变率比较,P<0.05.EGFR基因突变患者43例中,24例21外显子突变,占比55.81%,16例19外显子突变,占比44.19%.结论非小细胞肺癌患者EGFR基因外显子突变的主要突变位点为19/21外显子,与性别、吸烟、腺癌存在相关性.
Objective To study the relationship between exon mutations in the epidermal growth factor receptor(EGFR)gene and its clinicopathological characteristics in non-small-cell lung cancer.Methods With 100 non-small cell lung cancer patients treated by the Laboratory Department of Jiamusi Central Hospital,Heilongjiang Province,the study time was from March 2019 to March 2020,tumor cells were obtained,paraffin cell blocks were made,genetic test samples were obtained,EGFR mutation and clinical case characteristics were analyzed.Results Exon mutation of EGFR gene occurred in 43 patients(43.00%).Comparison of EGFR gene exon mutation rate in patients with different genders,smoking and adenocarcinoma(P<0.05).Among 43 patients with EGFR gene mutation,24 cases had exon 21 mutation,accounting for 55.81%,and 16 cases had exon 19 mutation,accounting for 44.19%.Conclusion Exon 19/21 is the main mutation site of EGFR gene in NSCLC patients,which is correlated with gender,smoking and adenocarcinoma.
作者
杨晓伟
金军英
YANG Xiao-wei;JIN Jun-ying(Clinical Laboratory of Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
出处
《医学信息》
2022年第S01期59-61,共3页
Journal of Medical Information
关键词
表皮生长因子受体
非小细胞肺癌
病例特征
基因外显子突变
epidermal growth factor receptor
non-small cell lung cancer
case characteristics
exonic gene exon mutations
