摘要
目的探究结肠癌肝转移患者治疗前外周血中性粒细胞-淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)与治疗的无进展生存时间之间(Progress Free Survival,PFS)的关系。方法回顾性收集我院25例接受一线化疗的结肠癌肝转移患者病历资料和化疗前外周血NLR值。分析NLR与患者一线化疗PFS的关系。结果低NLR组患者的PFS明显高于高NLR组(226.92±70.60 vs.150.38±56.60天,P=0.006)。生存分析也显示低NLR组患者的PFS明显高于高NLR组(P=0.0015)。NLR的受试者操作特征曲线下面积为0.7564,P=0.0296。当NLR=3时,诊断的敏感度为75.00%,特异度为76.92%。结论化疗前NLR值对结肠癌肝转移患者一线治疗的PFS有预测作用。NLR值越高,PFS越短。
Objective To investigate the relationship between the neutrophil-to-lymphocyte ratio(NLR)and the progression free survival time(PFS)of patients with colon cancer liver metastasis before treatment.Methods Medical records of 25 cases of colon cancer patients with liver metastasis who received first-line chemotherapy in our hospital and NLR value of peripheral blood before chemotherapy were collected retrospectively.The relationship between NLR and the PFS of first-line chemotherapy were analyzed.Results The PFS of patients in the low NLR group was significantly higher than that in the high NLR group(226.92±70.60 d vs.150.38±56.60 d,P=0.006).Survival analysis also showed that patients in the low NLR group had significantly higher PFS than those in the high NLR group(P=0.0015).The area under the receiver operator characteristic curve of NLR is 0.7564,P=0.0296.When NLR=3,the sensitivity of diagnosis is 75.00%and the specificity is 76.92%.Conclusion The pro-chemotherapy NLR has prognostic significance on PFS in first-line treatment of colon cancer patients with liver metastases.The higher the NLR value,the shorter the PFS.
作者
吴平利
李心忠
WU Ping-li;LI Xin-zhong(The People’s Hospital of Suixi,Suixi 231500,China)
出处
《肝胆外科杂志》
2020年第4期288-290,共3页
Journal of Hepatobiliary Surgery
关键词
中性粒细胞-淋巴细胞比值
结肠癌
肝转移癌
疗效预测
neutrophil-to-lymphocyte ratio
colon cancer
liver metastasis
prognostic significance
