摘要
作为冠状病毒,SARS-CoV-2和SARS-CoV都通过ACE2受体侵入宿主细胞。在临床上表现出新冠病毒对人体的攻击不单只是瞅准了肺部,而是多脏器受损,包括心血管、肾脏、消化道。新冠症状由最初的气短、咳嗽和发烧,但随后发现还有6个新冠症状,分别是畏寒、肌肉疼痛、头疼、喉咙疼以及突然失去嗅觉或者味觉等等。对抗新冠病毒的认知快速迭代,克敌制胜的招数不断升级。本文主要介绍了冠状病毒的结构和ACE2在SARS-CoV中的作用,总结了SARS-CoV-2新型冠状病毒的相关研究进展和可能的治疗药物的最新临床治疗效果,以便充分了解SARS-CoV-2的发展过程和药物研究方向,为后续研究提供了思路。
As a coronavirus,Both SARS-CoV-2 and SARS-CoV had been invaded host cells through ACE2 receptor.The SARS-CoV-2 was attacked not just the lungs on human body at clinical feature,It was multiple organ damage,including cardiovascular,kidney and digestive tract.The symptoms of SARS-CoV-2 were initially shortness of breath,cough and fever,but then 6 symptoms,chills,muscle aches,headaches,sore throats,sudden loss of smell or taste,etc.The cognition against COVID-19 had been iterated rapidly,the tactics of conquering the enemy was constantly upgraded.The structure and the role of ACE2 in SARS-CoV were mainly introduced in this review,the relevant research progress of SARS-CoV-2 and the latest clinical treatment effect of possible therapeutic drugs were summarized,in order to fully understand the development process and drug research direction of SARS-CoV-2,the train of thought was provided for follow-up research.
作者
顾觉奋
Gu Jue-fen(Institute of Life Science and Technology,China Pharmaceutical University,Nanjing 210009)
出处
《国外医药（抗生素分册）》
CAS
2020年第4期251-258,共8页
World Notes on Antibiotics
