摘要
颞叶癫痫是临床最常见的癫痫类型,近年来,越来越多研究发现颞叶癫痫患者在执行功能相关领域有不同程度的影响,这一影响不一定只存在于执行功能相关的某一项领域,可能在几项领域均有受影响,并且可能与癫痫发作起源部位等有关。然而目前为止,关于执行功能的组成还没有统一的标准,其中主要由工作记忆、抑制控制和认知灵活性/转换3个核心成分组成的理论被广泛接受。此外,2010年国际抗癫痫联盟提出新的定义,癫痫是一种脑网络疾病。而脑神经网络与认知障碍之间有着紧密联系。从认知领域划分,脑神经网络可分为6个,默认模式网络、突显网络、执行控制网络、背侧注意网络、躯体运动网络和视觉网络。近年来,越来越多的证据表明四个相关的内在大脑网络,参与一系列的认知过程。颞叶癫痫的执行功能障碍可能与神经网络的功能连通性变化有关,并且可能与左侧钩束有关。本文将从工作记忆、抑制控制和认知灵活性/转换3个方面对颞叶癫痫的执行功能相关研究进展进行回顾,并探讨颞叶癫痫神经网络改变与执行功能研究中的相关情况。
Temporal lobe epilepsy is the most common type of epilepsy in clinic.In recent years,many studies have found that patients with temporal lobe epilepsy have different degrees of influence in executive function related fields.This influence may not only exist in a certain field of executive function,but may be affected in several fields,and may be related to the origin site of seizures.However,up to now,there is no unified standard for the composition of executive function,and it is widely accepted that the three core components of executive function are working memory,inhibitory control and cognitive flexibility/switching.In addition,the International League Against Epilepsy proposed a new definition in 2010,and epilepsy is a brain network disease.There is a close relationship between brain neural network and cognitive impairment.According to the cognitive field,the brain neural network can be divided into six types:default mode network,salience network,executive control network,dorsal attention network,somatic motor network and visual network.In recent years,there has been increasing evidence that four related internal brain networks are series in a range of cognitive processes.The executive dysfunction of temporal lobe epilepsy may be related to the changes of functional connectivity of neural network,and may be related to the left uncinate fasciculus.This article reviews the research progress related to executive function in temporal lobe epilepsy from working memory,inhibitory control and cognitive flexibility,and discusses the correlation between the changes of temporal lobe epilepsy neural network and executive function research.
作者
韩清梅
王菊莉
HAN Qingmei;WANG Juli(School of Rehabilitation Medicine,Jiamusi University,Jiamusi 154003,China;Department of Epilepsy,the Central Hospital of Jiamusi,Jiamusi 154003,China)
出处
《癫痫杂志》
2023年第3期230-234,共5页
Journal of Epilepsy
关键词
颞叶癫痫
执行功能
工作记忆
默认模式网络
Temporal Lobe Epilepsy
Executive Function
Working Memory
Default Mode Network
