摘要
目的:系统评价地黄饮子治疗中风后失语的临床疗效及安全性。方法:通过计算机检索知网、万方、维普、SinoMed、CBM、PubMed、Embase等数据库,搜集关于地黄饮子治疗中风后失语的相关随机对照试验(RCTs),提取文献基本信息并进行质量评价和风险评估,最后采用RevMan 5.3软件进行Meta分析。结果:最终纳入14项RCTs进行Meta分析,共986例患者(试验组499例,对照组487例)。Meta分析结果显示:1.在提高汉语失语症评定量表(ABC)评分方面,地黄饮子联合西医加康复治疗优于单纯西医加康复治疗[MD=10.78,95%CI(7.57,14.00),P<0.00001];2.在提高失语症严重程度分级标准(BDAE)评分方面,地黄饮子联合西医加康复治疗优于单纯西医加康复治疗[MD=0.80,95%CI(0.14,1.46),P=0.02];3.在提高失语商(AQ)评分方面,地黄饮子联合西医加康复治疗优于单纯西医加康复治疗[MD=12.93,95%CI(6.65,19.22),P<0.00001]。结论:地黄饮子治疗中风后失语有着明显的临床疗效,提高患者各项语言功能评分,改善患者语言功能障碍,而且相对安全不良反应较小。
ObjectiveTo systematically evaluate the clinical efficacy and safety of Dihuang Yinzi in the treatment of aphasia after stroke.MethodsRandomized controlled trial(RCTs)related to the treatment of aphasia after stroke by Dihuang Yinzi were collected through computer retrieval of databases such as CNKI,Wanfang,VIP,SinoMed,CBM,PubMed,Embase,etc.The basic information of the literature was extracted,and the quality and risk assessment were carried out.Finally,RevMan 5.3 software was used for Meta analysis.Result14 RCTs were ultimately included for meta-analysis,with a total of 986 patients(499 in the treatment group and 487 in the control group).Meta analysis results showe that:1.In terms of improving the score of Chinese Aphasia Rating Scale(ABC),Dihuang Yinzi combined with western medicine and rehabilitation therapy is superior to the simple western medicine and rehabilitation therapy[MD=10.78,95%CI(7.57,14.00),P<0.0001];2.In terms of improving the grading standard of Aphasia severity(BDAE),Dihuang Yinzi combined with western medicine and rehabilitation treatment is superior to western medicine and rehabilitation treatment alone[MD=0.80,95%CI(0.14,1.46),P=0.02];3.In terms of improving Aphasia Quotient(AQ)scores,the combination of Dihuang Yinzi and Western medicine combined with rehabilitation treatment is superior to simple Western medicine combined with rehabilitation treatment[MD=12.93,95%CI(6.65,19.22),P<0.00001].ConclusionDihuang Yinzi has significant clinical efficacy in treating aphasia after stroke,improving patients'language function scores,improving their language dysfunction,and has relatively safe side effects.
出处
《黑龙江中医药》
2023年第5期158-161,共4页
Heilongjiang Journal of Traditional Chinese Medicine
