摘要
Notch信号家族是一组在进化上高度保守、可调节细胞发育及分化的跨膜蛋白。Notch信号通路在胰腺早期发育过程中扮演着重要角色,亦在胰腺炎和胰腺癌进展中表现出明显的活化。对Notch信号通路的合理调控有望为胰腺外分泌疾病的诊疗提供新见解。该文对Notch信号通路在胰腺炎症及肿瘤发生发展中所起作用的研究进展进行综述。
Notch signaling pathway is a group of trans-membrane proteins that can regulate development and differentiation cells.It is highly conserved in evolution.Notch signaling pathway plays an important role in the early development of the pancreas,and also shows significant activation in the progression of pancreatitis and pancreatic cancer.Rational regulation of Notch signaling pathway may provide a new insight into the diagnosis and treatment of pancreatic exocrine diseases.This review focuse on role of Notch signaling pathway in the development and progression of pancreatitis and pancreatic cancer.
作者
杨娟
许小凡
段丽芳
张红
Yang Juan;Xu Xiao-Fan;Duan Li-Fang;Zhang Hong(Basic Medical Department,Shaanxi University of Traditional Chinese Medicine,Xi’an 712046,China;Medical Research Experimental Center,Shaanxi University of Traditional Chinese Medicine,Xi’an 712046,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2020年第2期219-223,共5页
Medical Journal of Chinese People's Liberation Army
基金
国家自然科学基金(81673816)
胰、肝疾病的分子机制及中医药防治创新团队项目(2019-YL14)
陕西省自然科学基础研究一般项目(2018JM7085).
关键词
NOTCH信号通路
胰腺炎
胰腺癌
Notch signaling pathway
pancreatitis
pancreatic cancer
