摘要
神经性毒剂的急性、亚急性和慢性暴露均会引起中枢氧化应激。目前的医疗方法只能为神经性毒剂中毒提供有限的治疗和中枢保护作用。为预防神经性毒剂中毒造成继发性神经损伤,氧化应激正成为治疗神经性毒剂中毒的关键靶标。该文综述了神经性毒剂中毒后氧化应激的产生机制,以及用抗氧化剂治疗以减轻大脑氧化损伤、神经炎症和神经退行性病变的中枢保护策略研究进展。
Acute,subacute and chronic exposure to nerve agents will cause central oxidative stress.The medical treatments currently available can do nothing more than provide limited treatment and neuroprotection for nerve agent poisoning.In order to prevent secondary neuronal injury caused by nerve agents,oxidative stress is becoming a key target for the treatment of nerve agent toxicity.This review outlines the mechanism of oxidative stress after nerve agents poisoning,and the research progress in neuroprotective strategies,such as the use of antioxidant therapies to reduce brain oxidative stress,neuroinflammation and neurodegenerative diseases.
作者
卢彩红
龚伟
孟园园
孔晓龙
高春生
LU Cai⁃hong;GONG Wei;MENG Yuan⁃yuan;KONG Xiao⁃long;GAO Chun⁃sheng(Pharmaceutical College of Guangxi Medical University,Nanning 530021,China;State Key Laboratory of Antiviral Drugs and Toxicology,Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China)
出处
《军事医学》
CAS
2021年第10期793-797,801,共6页
Military Medical Sciences
基金
国家科技重大专项(2018ZX09711003-008)
关键词
神经性毒剂
氧化应激
乙酰胆碱酯酶
活性氧
抗氧化剂
nerve agent
oxidative stress
acetylcholinesterase
reactive oxygen species
antioxidant
