摘要
目的探讨简易认知量表(Mini-Cog)和8条目痴呆筛查问卷(8-item ascertain dementia,AD8)对80岁以上老年人群早期轻度认知功能障碍(mild cognitive impairment,MCI)的筛查价值。方法选取杭州市某福利中心的2014年10月前已入住的908名高龄老年人进行MiniCog和AD8筛查,随访5年后对仍然健在且能配合完成检查者进行二次认知功能评估。计算MiniCog和AD8初筛的敏感度和特异度,并分析随访5年后AD8的ROC曲线结果以及两种量表的一致性检验结果。结果908例高龄老年人中523例确诊为痴呆(不计入后续筛查及随访调查),余385例筛查结果显示:Mini-Cog、AD8诊断MCI的敏感度分别为54.88%、57.32%,特异度分别为85.52%、86.43%。随访5年后仍健在且接受二次评估的老年人共167名,其中认知功能正常106例(54例出现认知功能下降),MCI 61例(36例出现认知功能进一步下降)。对于随访5年的认知功能正常者及MCI者,AD8诊断的AUC分别为0.572(95%CI=0.486-0.658)、0.723(95%CI=0.611-0.835),Mini-Cog和AD8(以得分>3为分界线)诊断的一致性Kappa值分别为0.105、0.018和0.225、0.524。结论AD8和Mini-Cog均具有一定的MCI评估效能,尤其适用于养老机构及社区高龄老年群体的认知功能筛查。
Objective To investigate the value of Mini-Cog and 8-item ascertain dementia(AD8)in the diagnosis of mild cognitive impairment(MCI)and predicting cognitive deterioration in the 80 above years old population.Methods 908 elderly individuals who had been admitted to Hangzhou welfare center before October 2014 were selected for Mini-Cog and AD8 screening.After 5 years of follow-up,the second cognitive function assessment was performed on those who were still alive and able to complete the examination.The sensitivity and specificity of Mini-Cog and AD8 preliminary screening were calculated,the ROC curve results of AD8 and the consistency test results of the two scales after 5 years of follow-up were analyzed.Results Among the 908 elderly individuals,523 were diagnosed as dementia(not included in subsequent screening and follow-up).The remaining 385 individuals showed that the sensitivity of Mini-Cog and AD8 to diagnose MCI was 54.88%and 57.32%,and the specificity was 85.52%and 86.43%.A totally of 167 elderly people who were still alive and accepted the second assessment after five-years follow up,of which 106 cases had normal cognitive function(54 cases had cognitive function decline),and 61 cases of MCI(36 cases had further cognitive decline).For elderly people with normal cognitive function and MCI who were followed up for 5 years,the AUC for AD8 diagnosis was 0.572(95%CI=0.486-0.658),0.723(95%CI=0.611-0.835),the diagnostic consistency Kappa values of Mini-Cog and AD8(the cut-off value is over 3)were 0.105,0.018 and 0.225,0.524.Conclusion Both AD8 and Mini-Cog have a certain MCI evaluation performance,which is especially suitable for the cognitive function screening of elderly care institutions and communities.
作者
张思然
金煜
徐珊瑚
刘小利
Zhang Siran;Jin Yu;Xu Shanhu;Liu Xiaoli(Department of Neurology,Zhejiang Hospital,Hangzhou 310013,China)
出处
《中华老年病研究电子杂志》
2020年第2期17-21,共5页
Chinese Journal of Geriatrics Research(Electronic Edition)
基金
国家科技部港澳台合作项目(2014DFT30100)
浙江省科技厅项目(2015C33135、2014C33242)
浙江省卫生厅项目(2018267955)
浙江省医药卫生科技项目(2019KY260)
