摘要
目的探究龟板白术汤结合小脑顶核电刺激治疗缺血性脑卒中恢复期(肝肾亏虚证)患者疗效及安全性。方法纳入肝肾亏虚证缺血性脑卒中恢复期患者99例(2018年1月—2020年9月),将患者分为对照组50例、观察组49例。对照组患者西医常规(氯吡格雷)治疗,观察组患者采取氯吡格雷+龟板白术汤结合小脑顶核电刺激治疗,比较两组疗效、治疗前后患者中医症状(轻瘫及言语謇涩、头晕目眩及麻木、共济失调等)积分变化、神经胶质原纤维酸性蛋白(GFAP)及神经元特异性烯醇化酶(NSE)、神经损伤指标泛素羟基末端水解酶-1(UCH-L1)水平变化、神经功能缺损量表(NIHSS)评分变化及简明精神状态量表(MMSE)及日常生活活动能力量表(BI)评分变化、脑血流灌注指标变化与并发症。结果与对照组患者(84.00%,42/50)相比较,观察组患者治疗总有效率(95.92%,47/49)更高(P<0.05);治疗前,两组患者中医症状(轻瘫及言语謇涩、头晕目眩及麻木、共济失调等)积分、GFAP及NSE、UCH-L1水平、NIHSS及MMSE、BI量表评分、收缩期峰值流速(PSV)及平均流速(TMV)、阻力指数(RI)等比较差异无统计学意义(P>0.05),治疗后各组患者中医症状(轻瘫及言语謇涩、头晕目眩及麻木、共济失调等)积分、GFAP及NSE、UCH-L1水平、NIHSS及MMSE、BI量表评分、PSV、TMV及RI等指标均改善,观察组患者治疗后中医症状(轻瘫及言语謇涩、头晕目眩及麻木、共济失调等)积分、GFAP及NSE、UCH-L1水平、NIHSS及MMSE、BI量表评分、PSV、TMV及RI等指标均优于对照组(P<0.05);与对照组(14.00%,7/50)比较,观察组患者并发症率(2.04%,1/49)更低(P<0.05)。结论小脑顶核电刺激与龟板白术汤结合治疗缺血性脑卒中恢复期(肝肾亏虚证)疗效显著,患者恢复好,安全可靠。
Objective To explore the efficacy and safety of Guiban Baizhu Decoction(龟板白术汤)combined with cerebellar fastigial nuclear stimulation in the treatment of patients with ischemic stroke during convalescence(liver-kidney deficiency syndrome).Methods A total of 99 patients with ischemic stroke in convalescent stage of liver and kidney deficiency syndrome(January 2018 to September 2020)were included.The patients were divided into two groups:control group(50 cases)and observation group(49 cases).Patients in the control group received conventional Western medicine treatment(clopidogrel),while those in the observation group received clopidogrel and Guiban Baizhu Decoction combined with cerebellar fastigial nuclear stimulation.The curative effects of the two groups,the integral changes of traditional Chinese medicine symptoms(paraplegia and speech jerkiness,dizziness,numbness,ataxia,etc.)before and after treatment,the changes of glial fibrillary acidic protein(GFAP)and neuron specific enolase(NSE),the level of ubiquitin hydroxyl terminal hydrolase-1(UCH-L1),the national institute of health stroke scale(NIHSS)score changes,mini-mental state examination(MMSE)and activity of daily living scale(BI)score changes,cerebral blood flow perfusion index changes and complications were compared.Results Compared with that(84.00%,42/50)of the control group,the total effective rate(95.92%,47/49)of observation group was higher(P<0.05).Before treatment,the scores of TCM symptoms(paraplegia and speech jerkiness,dizziness,numbness,ataxia,etc.),the levels of GFAP,NSE and UCH-L1,the scores of NIHSS,MMSE and BI,the values of systolic peak velocity(PSV)and mean velocity(TMV),resistance index(RI)of two groups were not significant(P>0.05).After treatment,the above indicators were improved in each group.And those in the observation group were better than those in the control group(P<0.05).Compared with that(14.00%,7/50)in the control group,the complication rate(2.04%,1/49)in the observation group was lower(P<0.05).Conclusion The combinatio
作者
陈昭
魏志强
CHEN Zhao;WEI Zhiqiaing(Second Hospital of Tianjin Medical University,Tianjin 300211,China)
出处
《辽宁中医杂志》
CAS
2022年第9期191-194,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
国家重点研发计划课题(2018YFC1314304)
关键词
缺血性脑卒中恢复期
肝肾亏虚证
龟板白术汤
小脑顶核电刺激
疗效
并发症
recovery period of ischemic stroke
deficiency of liver and kidney syndrome
Guiban Baizhu Decoction(龟板白术汤)
fastigial nuclear stimulation
curative effect
complications
