摘要
目的探讨葶苈大枣泻肺汤合桂枝茯苓丸联合西医常规治疗慢性阻塞性肺疾病(COPD)急性发作期痰瘀阻肺证的临床疗效。方法筛选2018年2月—2020年2月亳州市中医院收治的COPD急性加重期患者108例,按随机数字表法分为两组各54例。对照组予常规西医治疗,观察组同时予葶苈大枣泻肺汤合桂枝茯苓丸内服。两组连续治疗2周。比较两组疾病严重程度、肺功能、临床疗效以及血清降钙素原(PCT)、C反应蛋白(CRP)水平。结果治疗后,两组改良版英国医学研究委员会呼吸问卷(mMRC)和自我评估测试问卷(CAT)评分明显降低,且观察组显著低于对照组(P<0.01);治疗后,两组第1秒用力呼气量(FEV1)和FEV1/用力肺活量(FVC)显著增加,且观察组显著高于对照组(P<0.01);观察组的总有效率显著高于对照组(P<0.05);治疗后,两组血清PCT和CRP水平明显降低,且观察组显著低于对照组(P<0.01)。结论在常规西药治疗基础上葶苈大枣泻肺汤合桂枝茯苓丸对COPD急性发作期痰瘀阻肺证的疗效确切,且可改善炎性反应。
Objective To investigate the efficacy of Tingli Dazao Xiefei Decoction(葶苈大枣泻肺汤)and Guizhi Fulin Pill(桂枝茯苓丸)combined with conventional Western medicine in the treatment of acute attack stage of chronic obstructive pulmonary disease(COPD)with syndrome of phlegm-stasis obstructing the lung.Methods One hundred and eight cases with acute exacerbation stage of COPD admitted to the hospital from February of 2018 to February of 2020 were selected and divided into the control group and the observation group with 54 patients in each group according to the random number table method.The control group was given with traditional Chinese medicine,and the observation group was treated with Tingli Dazao Xiefei Decoction and Guizhi Fulin Pill.The two groups were continuously treated for 2 weeks.The disease severity,lung function,the clinical efficacy,and serum levels of procalcitonin(PCT)and C-reactive protein(CRP)were compared for both groups.Results After treatment,scores of modified version of the British medical research council’s respiratory questionnaire(m MRC)and COPD patients self-assessment test questionnaire(CAT)of of the two groups were significantly decreased,and the observation group was significantly lower than the control group(P<0.01).After treatment,forced expiratory capacit(yFEV1)and FEV1/Forced vital capacit(yFVC)were significantly increased in both groups,and the observation group was significantly higher than the control group(P<0.01).Total effective rate of observation group was evidently higher than control group(P<0.05).After treatment,the serum PCT and CRP levels in both groups were significantly decreased,and the observation group was significantly lower than the control group(P<0.01).Conclusion Effect of Tingli Dazao Xiefei Decoction and Guizhi Fulin Pill combined with conventional western medicine in the treatment of acute attack stage of COPD with syndrome of phlegm-stasis obstructing the lung is significantly and can improve the inflammation.
作者
李广州
邓娣
刘强
马云飞
王可
LI Guangzhou;DENG Di;LIU Qiang;MA Yunfei;WANG Ke(Bozhou Hospital of Traditional Chinese Medicine,Bozhou 236800,Anhui,China)
出处
《辽宁中医药大学学报》
CAS
2021年第8期206-209,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
亳州市华佗中医院专项基金(2017lckyhtzyy04)
安徽省医学会临床研究项目(Ky2018018)
关键词
慢性阻塞性肺疾病
葶苈大枣泻肺汤
桂枝茯苓丸
痰瘀阻肺证
chronic obstructive pulmonary disease patients
Tingli Dazao Xiefei Decoction(葶苈大枣泻肺汤)
Guizhi Fulin Pill(桂枝茯苓丸)
syndrome of phlegm-stasis obstructing the lung
