摘要
浆细胞肿瘤相关贫血的发生主要与克隆性浆细胞无限制增殖密切有关,其他如Fas-L/TRAIL介导的红系前体细胞凋亡增加、细胞因子抑制红系造血、铁代谢异常和促红细胞生成素生成异常也参与其中。贫血的治疗主要是针对浆细胞病的治疗,输注红细胞、红细胞造血刺激剂和补充造血原料为辅助治疗。
The occurrence of plasma cell tumor-related anemia is closely associated with the unrestricted proliferation of clonal plasma cells.Other mechanisms include Fas-L/TRAIL-mediated increased apoptosis of erythroid precursor cells,cytokine inhibiting erythropoiesis,and abnormal iron metabolism and erythropoietin production.The treatment for plasma cell tumor-associated anemia is mainly the treatment for plasma cell disease.Other treatments include infusion of red blood cells,erythropoiesis-stimulating agents and supplementation of hematopoietic materials which are used as adjuvant therapies.
作者
张晓慧
李炳宗
ZHANG Xiao-hui;LI Bing-zong(Department of Hematology,the Second Affiliated Hospital of Soochow University,Suzhou 215004,China)
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2020年第9期709-712,共4页
Chinese Journal of Practical Internal Medicine
基金
国家自然科学基金(81670191)
江苏省社会发展项目(SBE2019740362)
苏州市临床重点病种诊疗技术专项(LCZX201805)
苏州市民生科技关键技术应用研究(SS201856)
关键词
浆细胞肿瘤
贫血
凋亡
细胞因子
红细胞刺激剂
plasma cell tumor
anemia
apoptosis
cytokine
erythropoiesis-stimulating agents
