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120例AIDS患者合并马尔尼菲篮状菌血流感染的回顾性分析

Retrospective analysis of 120 AIDS patients with Talaromycosis marneffei bloodstream infection in Margny
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摘要 目的了解贺州市艾滋病(AIDS)患者合并马尔尼菲篮状菌(TM)血流感染的基本情况,评估临床医生对马尔尼菲篮状菌病(TSM)的诊断能力和救治水平。方法收集2019-2022年贺州市确诊为TM血流感染的AIDS住院患者的临床资料120份,对患者的基本信息、药物治疗方案、药物诱导治疗疗效进行整理、统计及回顾性分析。结果120例患者中男性96例,女性24例。根据患者初步诊断及药物治疗进行分组统计,第1组(针对性抗真菌组)有16例,调整方案后治疗有效率为75.0%;第2组(非针对性抗真菌组)有51例,调整方案后治疗有效率为66.7%;第3组(抗细菌组)有53例,调整方案后治疗有效率为56.6%。临床医生对TSM的早期诊断率不高,仅16例(占比13.33%)。经调整方案后中有76例患者治疗有效,总有效率为63.3%,其中32例使用伊曲康唑(占42.11%),21例使用两性霉素B(占27.63%),17例使用伏立康唑(占22.37%),6例使用氟康唑(占7.89%)。结论贺州市临床医生对TSM的早期诊断率不高,三组方案中第1组有效率最高,该院针对AIDS患者合并TM血流感染的药物治疗方案是规范的、合理的、有效的。 Objective To understand the basic situation of HIV/AIDS patients in Hezhou with blood stream infection caused by basket-shaped bacteria(TM),and to evaluate the diagnostic ability and treatment level of clinicians for basket-shaped bacteria(TSM).Methods A total of 120 clinical data of hospitalized AIDS patients with TM bloodstream infection in Hezhou were collected.The basic information,drug treatment and prognosis of the patients were analyzed,a retrospective analysis was performed.Results Of all the 120 patients,96 cases were male and 24 cases were female.According to the initial diagnosis and drug treatment,16 patients in the first group were treated with antifungal therapy,and the effective rate was 75.0%after adjusting the treatment regimen There were 51 cases in Group 2(non-targeted antifungal group),the effective rate was 66.7%after adjusting the treatment regimen,and 53 cases in Group 3(anti-bacterial group),the effective rate was 56.6%after adjusting the treatment regimen.Only 16 cases(13.33%)were diagnosed as TSM in early stage.The total effective rate was 63.3%after adjusting the treatment regimen.Among them,32 cases used Itraconazole(42.11%),21 cases used Amphotericin B b(27.63%),17 cases used Voriconazole(22.37%),fluconazole was used in 6 cases(7.89%).Conclusion The rate of early diagnosis of TSM by clinicians in Hezhou is not high.The drug treatment program for AIDS patients with TM bloodstream infection in our hospital is standardized,reasonable and effective.
作者 张欢 梁立全 卢云 刘少烽 ZHANG Huan;LIANG Liquan;LU Yun;Liu Shaofeng(Hezhou People′s Hospital.Hezhou,Guangxi,542899,China)
机构地区 贺州市人民医院
出处 《新疆医学》 2024年第6期670-673,共4页 Xinjiang Medical Journal
基金 广西贺州市科学研究与技术开发项目(项目编号:贺科攻1908019,贺科技20022)
关键词 艾滋病 马尔尼非蓝状菌 血流感染 回顾性分析 AIDS Talaromycosis marneffei Bloodstream infection Retrospective analysis
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