摘要
目的:调查吸毒途径HIV感染者发生焦虑障碍与抑郁障碍的发病率及风险因素。方法:在20个艾滋病治疗机构的HIV感染者中进行横断面调查,收集吸毒途径HIV感染者社会人口学特征及HIV相关临床数据,医院焦虑与抑郁量表及匹兹堡睡眠质量指数评估感染者焦虑障碍、抑郁障碍和睡眠障碍。结果:与非吸毒途径的HIV感染者相比,吸毒途径HIV感染者出现精神障碍的比例显著更高,焦虑障碍、抑郁障碍、焦虑障碍合并抑郁障碍的患病率分别为33.3%、45.9%和27.8%。logistic回归分析表明,吸毒途径HIV感染者发生焦虑障碍的相关因素包括睡眠障碍(OR,4.357;95%CI,2.078~9.136;P<0.001),发生抑郁障碍的相关因素包括睡眠障碍(OR,4.102;95%CI,2.259~7.451;P<0.001),二者均发生的相关因素包括睡眠障碍(OR,5.433;95%CI,2.634~11.205;P<0.001)和社会与家人的支持(OR,0.441;95%CI,0.218~0.894;P=0.023)。结论:吸毒途径HIV感染者发生焦虑障碍或抑郁障碍的患病率很高,主要与睡眠障碍及社会支持因素有关。
Objective:To investigate the prevalence and risk factors of anxiety disorders and depressive disorders in people living with HIV(PLWH)through drug use.Methods:This was a cross-sectional survey conducted among PLWHs on antiretroviral therapy at 20 AIDS clinics.The sociodemographic characteristics and HIV-related clinical data of HIV infected persons through drug abuse routes were collected.The Hospital Anxiety and Depression and Pittsburgh Sleep Quality Index were used to assess anxiety disorders,depressive disorders and sleep disorders,respectively.Results:Compared with non-drug-taking HIV-infected people,people infected with HIV through drug abuse had significantly higher rates of mental disorders.The prevalence rates of anxiety disorder,depressive disorder and anxiety disorder with depressive disorder were 33.3%,45.9%and 27.8%,respectively.Logistic regression analysis showed that risk factors for anxiety disorders in HIV-infected persons who take drugs include sleep disorders(OR,4.357;95%CI,2.078~9.136;P<0.001),and risk factors for depressive disorders include sleep disorders(OR,4.102;95%CI,2.259~7.451;P<0.001),and risk factors for the occurrence of both include sleep disorders(OR,5.433;95%CI,2.634~11.205;P<0.001)and support from society and family(OR,0.441;95%CI,0.218~0.894;P=0.023).Conclusion:The prevalence of anxiety disorder or depressive disorder in HIV infected people through drug abuse is very high,which is mainly related to sleep disorders and social support factors.
作者
朱文娇
张洋
李爱新
高美霞
邓佳慧
张彤
吴昊
黄晓婕
陈官芝
ZHU Wenjiao;ZHANG Yang;LI Aixin;GAO Meixia;DENG Jiahui;ZHANG Tong;WU Hao;HUANG Xiaojie;CHEN Guanzhi(The Affiliated Hospital of Qingdao University,Qingdao,266003,China;Center for Infectious Disease,Beijing Youan Hospital,Capital Medical University,Beijing,100069,China;Beijing Key Laboratory of HIV/AIDS Research,Beijing Youan Hospital,Capital Medical University,Beijing,100069,China;Peking University Sixth Hospital,Beijing,100191,China;Institute of Mental Health,Peking University,Beijing,100191,China;National Key Laboratory of Mental Health,National Health Commission,Beijing,100871,China;National Clinical Research Center for Mental and Psychological Diseases(Peking University Sixth Hospital),Beijing,100191,China)
出处
《中国药物依赖性杂志》
CAS
CSCD
2020年第6期441-449,共9页
Chinese Journal of Drug Dependence
基金
国家自然科学基金青年科学基金(81901089)
中国博士后科学基金面上资助(2019M660718)
国家科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项(2017ZX10201101、2017ZX10202101)
北京市科技计划(D161100000416003)
北京市优秀人才青年拔尖个人项目(2018000021223ZK04)
北京市博士后科学基金国际交流培养资助派出项目(2019PC-11)
艾滋病研究北京市重点实验室(BZ0089)
艾滋病研究北京市重点实验室开放课题(BJYAHKF2019001)
关键词
HIV感染
吸毒
焦虑障碍
抑郁障碍
睡眠障碍
HIV infection
drug use
anxiety disorders
depressive disorders
sleep disorders
