摘要
目的:探讨脊柱受累的SAPHO综合征(滑膜炎-痤疮-脓疱病-骨质增生-骨炎)患者临床特点。方法:回顾性分析2013年1月至2020年10月住院诊治的48例SAPHO综合征患者的临床资料,根据脊柱受累与否分为脊柱型和非脊柱型,分析两组患者的一般特点、临床表现、影像学表现、实验室及病理学检查结果。结果:48例SAPHO综合征患者中脊柱型32例(66.7%)、非脊柱型16例(33.3%);与非脊柱型相比,脊柱型患者年龄偏大[(54.5±10.8)vs.(48.6±10.3)岁,P<0.05]、更多出现椎体部位疼痛(84.4%vs.18.8%,P=0.001)、C反应蛋白较高[9.8(3.2,20.5)mg/L vs.3.1(1.2,7.6)mg/L,P=0.024]。腰椎受累概率最高,其次为胸椎、颈椎(26.3%、19.3%、3.1%,P<0.01)。影像学检查提示患者总受累椎体数为123个,连续型共90个,胸椎病变椎体数最多,其次为腰椎、颈椎(74、42、7个,P<0.01)。结论:脊柱型SAPHO综合征常见,此类患者年龄偏大,多出现病变椎体部位疼痛,炎症反应更强烈,影像学检查可发现椎体病变多分布于胸腰椎。
Objective:To investigate the clinical characteristics of SAPHO syndrome patients with spinal involvement.Methods:The clinical data of 48 patients with SAPHO syndrome hospitalized from January 2013 to October 2020 were retrospectively analyzed.All patients were divided into two groups as spinal group and non-spinal group based on the presence of spinal lesions.The general characteristics,clinical manifestations,imaging findings,laboratory and pathological findings of the two groups were analyzed.Results:Among 48 patients with SAPHO syndrome,32(66.7%)were spinal type and 16(33.3%)were non-spinal type.The patients in spinal group were more older[(54.5±10.8)vs.(48.6±10.3)years old,P<0.05],there were more patients with pain in the vertebral bodies(84.4%vs.18.8%,P=0.001),and higher CRP[9.8(3.2,20.5)mg/L vs.3.1(1.2,7.6)mg/L,P=0.024]compared with the non-spinal group.The lumbar spine was most frequently involved,followed by the thoracic and cervical spine(26.3%,19.3%,3.1%;P<0.01).The imaging suggested that the total number of affected vertebral bodies was 123,among which 90 were continuous type.Thoracic spine lesions were the most,followed by lumbar spine and cervical spine(74,42,7;P<0.01).Conclusions:Spinal type SAPHO syndrome is common in older people with pain in the vertebral bodies and intense inflammatory reaction,and lesions are often located in the thoracolumbar spine.
作者
曹振鲁
丛亚男
刘斌
殷楚强
王月磊
王志超
刘宸境
王亭
CAO Zhenlu;CONG Ya'nan;LIU Bin;YIN Chuqiang;WANG Yuelei;WANG Zhichao;LIU Chenjing;WANG Ting(Department of Spine Surgery,The Affiliated Hospital of Qingdao University,Qingdao 266003,Shandong,China;Health Mangement Center,The Affiliated Hospital of Qingdao University,Qingdao 266003,Shandong,China;Department of Rheumatology and Immunology,The Affiliated Hospital of Qingdao University,Qingdao 266003,Shandong,China)
出处
《中华骨与关节外科杂志》
2022年第4期241-247,共7页
Chinese Journal of Bone and Joint Surgery
基金
青岛市惠民科技计划项目(21-1-4-rkjk-2-nsh)
