摘要
Pluripotent stem cells hold tremendous promise for regenerative medicine.The mechanisms underlying the acquisition and loss of pluripotency have been revealed at multiple levels.Subcellular mechanisms such as metabolic and organelle remodeling are emerging as critical for pluripotent cell fate transitions.Understanding the rules and roles of organelle remodeling will not only provide important insights into pluripotency regulation,but also help improving application in regenerative medicine.In this review,we summarize recent discoveries in organelle remodeling during the acquisition and loss of pluripotency and discuss how membrane lipids orchestrate organelle remodeling and drive nuclear gene expression.
Pluripotent stem cells hold tremendous promise for regenerative medicine. The mechanisms underlying the acquisition and loss of pluripotency have been revealed at multiple levels. Subcellular mechanisms such as metabolic and organelle remodeling are emerging as critical for pluripotent cell fate transitions. Understanding the rules and roles of organelle remodeling will not only provide important insights into pluripotency regulation, but also help improving application in regenerative medicine. In this review, we summarize recent discoveries in organelle remodeling during the acquisition and loss of pluripotency and discuss how membrane lipids orchestrate organelle remodeling and drive nuclear gene expression.
作者
WU Yi
CHEN KeShi
XIANG Ge
YING ZhongFu
LIU XingGuo
邬毅;陈可实;项鸽;应仲富;刘兴国(CAS Key Laboratory of Regenerative Biology,Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine,Joint School of Life Sciences,Institute for Stem Cell and Regeneration,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou510530,China)
基金
supported by the National Key Research and Development Program of China(2018YFA0107100)
the National Natural Science Foundation of China(Grant Nos.31622037and 31631163001).
