摘要
目的观察嗜酒者中脂肪肝与代谢异常患病的关系。方法2001年1月至2002年12月在上海宝钢集团股份有限公司体检中心参加体检的14578位职工中,根据定义识别男性嗜酒者,观察该人群脂肪肝和代谢异常患病的关系。结果共有男性嗜酒者2792人,其中474人(17.0%)患有脂肪肝。伴有脂肪肝者的体重指数为(26.98±2.46)kg/m2、收缩压(129.87±15.38)mmHg、舒张压(88.69±9.77)mmHg、甘油三酯(2.46±1.90)mmol/L、总胆固醇(5.51±0.96)mmol/L和空腹血糖(6.05±1.22)mmol/L明显均高于无脂肪肝者(23.70±2.69)kg/m2、(121.06±14.56)mmHg、(82.28±9.86)mmHg、(1.52±1.38)mmol/L、(4.95±0.91)mmol/L、(5.54±0.97)mmol/L(均P<0.001)。与无脂肪肝者相比,伴有脂肪肝者有更高的代谢异常包括肥胖(80.0%比30.8%)、高血压(60.8%比30.6%)、高三酰甘油血症(61.8%比25.9%)、高总胆固醇血症(42.2%比19.4%)和糖尿病(18.8%比8.1%)的患病率(均P<0.05)。多变量Logistic分析发现,高三酰甘油血症(P<0.001)、高总胆固醇血症(P=0.044)和糖尿病(P=0.004)是嗜酒者合并脂肪肝的影响因素。结论在男性嗜酒者中,脂肪肝不仅仅是酒精性肝损伤的表现,它的存在也提示更高的代谢异常发生率。
Objective To investigate the relationship between fatty liver and metabolic abnormalities in subjects with excessive alcohol intake.Methods Among the employees of the Bao-Steel Group(Shanghai,China),males with excessive alcohol intake were identified,and their medical records from check-ups were analyzed.The association between fatty liver and the prevalence of metabolic abnormalities was assessed among them.Results Two thousand seven hundred and ninetytwo males with excessive alcohol intake were identified,and the prevalence of fatty liver was 17.0%.The average levels of body mass index(26.98±2.46 kg/m2 vs.23.70±2.69 kg/m2),systolic blood pressure(129.87±15.38 mmHg vs.121.06±14.56 mmHg),diastolic blood pressure(88.69±9.77 mmHg vs.82.28±9.86 mmHg),serum triglycerides(2.46±1.90 mmol/L vs.1.52±1.38 mmol/L),total cholesterol(5.51±0.96 mmol/L vs.4.95±0.91 mmol/L)and fasting glucose(6.05±1.22 mmol/L vs.5.54±0.97 mmol/L)were all significantly higher in the individuals with fatty liver than those without(all P<0.001).The prevalence of metabolic abnormalities including obesity(80.0%vs.30.8%),hypertension(60.8%vs.30.6%),hypertriglyceridemia(61.8%vs.25.9%),hypercholesterolemia(42.2%vs.19.4%)and diabetes mellitus(18.8%vs.8.1%)were all higher in the individuals with fatty liver(all P<0.05).Even in nonobese individuals,fatty liver was still significantly associated with higher prevalence of hypertriglyceridemia(P<0.001),hypercholesterolemia(P=0.044)and diabetes mellitus(P=0.004).Conclusion In men with excessive alcohol intake,fatty liver is not merely a manifestation of alcoholic liver injury,but an indicator for a higher prevalence of metabolic abnormalities.Thus,in this population,those with fatty liver should be paid more attention to the identification and treatment of the related metabolic abnormalities.
作者
季蕾
范建高
李锋
JI Lei;FAN Jian-gao;LI Feng(Department of Gastroenterology,Zhongshan Hospital Affiliated to Fudan University,Shanghai 200032,China)
出处
《肝脏》
2020年第12期1309-1312,共4页
Chinese Hepatology
基金
国家自然科学基金(81670513)
上海市青年科技启明星计划(13QA1400700)
上海市卫生系统优秀青年医学人才培养计划(XYQ2013089)
关键词
嗜酒
脂肪肝
代谢异常
患病率
Excessive alcohol intake
Fatty liver
Metabolic abnormality
Prevalence
