摘要
目的探讨谷红注射液联合丁苯酞注射液治疗急性脑梗死的临床疗效。方法选取2016年1月—2017年6月亳州市人民医院收治的急性脑梗死患者136例,随机分成对照组(68例)和治疗组(68例)。对照组静脉滴注丁苯酞氯化钠注射液,100 mL/次,2次/d,两次给药间隔>6 h。治疗组在对照组的基础上静脉滴注谷红注射液,20 mL加入生理盐水250 mL,1次/d。两组患者均连续治疗14 d。观察两组患者临床疗效,比较治疗前后两组患者美国国立卫生研究院卒中量表(NIHSS)和Barthel指数、血液流变学指标、以及血清肿瘤坏死因子-α(TNF-α)和丙二醛(MDA)水平。结果治疗后,对照组和治疗组临床总有效率分别为82.35%、94.12%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者NIHSS评分明显降低,Barthel评分显著升高,同组比较差异具有统计学意义(P<0.05);且治疗组NIHSS评分和Barthel指数均显著优于对照组(P<0.05)。治疗后,两组患者全血高切黏度、全血低切黏度、血小板聚集率、血细胞比容均显著降低(P<0.05);且治疗组各项血液流变学指标水平比对照组更低(P<0.05)。治疗后,两组血清MDA水平均显著降低,治疗组患者血清TNF-α水平明显降低,同组比较差异有统计学意义(P<0.05);且治疗组血清TNF-α和MDA水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论谷红注射液联合丁苯酞注射液治疗急性脑梗死能有效改善患者机体血液流变学与微循环状态,减轻神经功能缺损。
Objective To evaluate the clinical efficacy of Guhong Injection combined with butylphthalide in treatment of acute cerebral infarction. Methods Patients（136 cases） with acute cerebral infarction in Bozhou People＇s Hospital from January 2016 to June 2017 were randomly divided into control（68 cases） and treatment（68 cases） groups. Patients in the control group were iv administered with Butylphthalide and Sodium Chloride Injection, 100 mL/time, twice daily, and the interval time using medicine was more than 6 h. Patients in the treatment group were iv administered with Guhong Injection on the basis of the control group, 20 mL added into normal saline 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the NIHSS and Barthel index scores, hemorheology indicators, serum TNF-α and MDA levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 82.35% and 94.12%, respectively, and there were differences between two groups（P〈0.05）.After treatment, the NIHSS score in two groups was significantly decreased, but the Barthel score was significantly increased, and the difference was statistically significant in the same group（P〈0.05）. And NIHSS and Barthel scores in the treatment group was better than those in the control group（P〈0.05）. After treatment, the whole blood high viscosity, whole blood low viscosity, platelet aggregation rate, and hematocrit in two groups were significantly decreased, and there were differences in the same group（P〈0.05）. And these hemorheology indicators in the treatment group were significantly lower than those in the control group（P〈0.05）. After treatment, the MDA level in two groups was significantly decreased, but TNF-α level in the treatment group was significantly decreased, and there were differences in the same group（P〈0.05）. After treatment, The TNF-α and MDA levels in the treat
出处
《现代药物与临床》
CAS
2018年第1期41-45,共5页
Drugs & Clinic
