摘要
目的:观察槐杞黄颗粒预防支气管哮喘儿童呼吸道感染的临床疗效。方法:将72例支气管哮喘患儿随机分成治疗组和对照组,每组36例。两组患儿均给予沙美特罗替卡松雾化吸入及孟鲁司特钠口服,治疗组在此基础上给予槐杞黄颗粒口服,治疗周期为3个月。观察并比较两组患儿的感染发生情况、免疫功能、肺功能,采用中文版儿童哮喘控制测试问卷(Ch-CACT)对两组患儿进行评估。结果:整个研究期间,治疗组的感染率为21.9%,对照组为34.3%,两组比较差异有统计学意义(P<0.05)。治疗后及随访3个月时,治疗组患儿的IgA、IgG、IgM水平及CD3+、CD4+、CD4+/CD8+较治疗前均显著升高(P<0.05),IgE水平显著降低(P<0.05);随访3个月时,对照组患儿的IgA、IgG、IgM水平及CD3+、CD4+、CD8+、CD4+/CD8+亦显著升高(P<0.05),IgE水平显著降低(P<0.05);且治疗后及随访3个月时,治疗组患儿的IgA、IgG、IgM水平及CD3+、CD4+、CD4+/CD8+较对照组亦显著升高(P<0.05)。治疗后及随访3个月时,两组患儿的FEV1、PEF、Ch-CACT评分较治疗前均显著升高(P<0.05)。结论:槐杞黄颗粒能明显改善支气管哮喘儿童的免疫功能,降低其感染及哮喘发作的次数,对支气管哮喘儿童反复呼吸道感染具有较好的预防作用。
Objective： To observe the clinical effect of ＂Huaiqihuang Granule＂ for preventing respiratory infections in children with bronchial asthma. Methods： Seventy-two children with bronchial asthma were randomly divided into treatment group and control group with 36 cases in each group. All the children were treated with salmeterol and fluticasonc propionate inhaled and montelukast sodium orally, and the treatment group was treated with ＂Huaiqihuang Granule＂ in addition, with a course of 3 months. The infection occurrence, immune function and lung function were observed and compared, and all the children were evaluated by Chinese-Childhood Asthma Control Test （Ch-CACT）. Results： Throughout the study period, the ratio of infection was 21.9% in the treatment group, and the ratio of infection in the control group was 34.3%, with statistical difference between two groups （P 〈0.05）. After treatment and three months after treatment, the levels of IgA, IgG, IgM, CD3^＋, CD4^＋ and CD4^＋/CD8^＋ in treatment group were significantly increased （P 〈 0. 05 ）, and the level of IgE was significantly decreased （P 〈 0.05） ; 3 months after treatment, the levels of IgA, IgG, lgM, CD3 ^＋ , CD4 ^＋ , CD8^＋ and CD4^＋/CD8^＋ in control group were also obviously increased （ P 〈 0.05 ） , and the level of IgE was significantly decreased （P〈0.05） ; and after treatment and three months after treatment, the levels of IgA, IgG, IgM, CD3^＋ , CD4^＋ and CD4^＋/ CD8 ^＋ in treatment group were higher than those in control group （ P 〈 0.05 ）. After treatment and three months after treatment, the levels of FEV1 and PEF and the scores of Ch-CACT in both groups were significantly higher than before treatment （ P 〈 0.05 ）. Conclusion ： ＂Huaiqihuang Granule＂ can improve the immune function, reduce the occurrences of infection and asthma, and prevent the respiratory infections in children with bronchial asthma.
出处
《上海中医药大学学报》
CAS
2014年第3期39-42,共4页
Academic Journal of Shanghai University of Traditional Chinese Medicine
关键词
槐杞黄颗粒
支气管哮喘
儿童
呼吸道感染
＂Huaiqihuang Granule＂
bronchial asthma
child
respiratory infections
