摘要
目的:探讨与分析艾滋病(AIDS)相关病原体及血清相关指标在男性AIDS患者中的检测价值。方法:选择男性同性恋AIDS患者80例作为AIDS组,选择同期健康体检的男性80例作为对照组,检测血清IL-10、TGF-β1含量与HCV、HBV、TP抗体阳性表达情况,检测全血CD 4+CD 28+、CD 4+CD 45 RA+、CD 4+CD 45 RO+、CD 4+CD 25+细胞比例并进行相关性分析。结果:AIDS组的血清IL-10和TGF-β1含量和血清HCV、HBV与TP抗体阳性率显著高于对照组(P<0.05)。AIDS组全血的CD 4+CD 28+、CD 4+CD 45 RA+、CD 4+CD 45 RO+细胞比例显著低于对照组(P<0.05)。Pearson相关分析显示,在AIDS组中,患者全血CD 4+CD 28+、CD 4+CD 45 RA+、CD 4+CD 45 RO+细胞比例与血清TGF-β1、IL-10以及HCV、HBV、TP抗体水平存在相关性(P<0.05)。结论:男性AIDS患者多表现为血清IL-10和TGF-β1的高表达,也多伴随有HCV、HBV、TP抗体表达阳性,与患者的免疫功能密切相关。
Objective:To explore and analyze the detection value of AIDS-related pathogens and serum indicators in male AIDS patients.Methods:80 cases of male homosexual AIDS patients were selected as AIDS group,and 80 cases of males who underwent physical examination at the same period were selected as control group.The serum levels of IL-10,TGF-β1,and positive expression of HCV,HBV,and TP antibodies were detected.The proportion of CD 4+CD 28+,CD 4+CD 45 RA+,CD 4+CD 45 RO+,and CD 4+CD 25+cells in the whole blood were detected,and the correlation was analyzed.Results:The serum levels of IL-10 and TGF-β1,and the positive rates of serum HCV,HBV,and TP antibodies in AIDS group were higher than those in control group(P<0.05).The proportions of CD 4+CD 28+,CD 4+CD 45 RA+,CD 4+CD 45 RO+cells in whole blood of AIDS group were lower than those of control group(P<0.05).In AIDS group,Pearson analysis showed that the proportions of CD 4+CD 28+,CD 4+CD 45 RA+,CD 4+CD 45 RO+cells in whole blood were correlated with the levels of serum IL-10,TGF-β1,HCV,HBV,and TP antibodies(P<0.05).Conclusions:Male homosexual AIDS patients mostly show high expression of serum TGF-β1 and IL-10,which are often accompanied by positive expression of HCV,HBV,and TP antibodies,which are closely related to patients’immune function.
作者
石英
徐苏丽
SHI Ying;XU Suli(Department of Laboratory,Yan’an Center for Disease Control and Prevention,Shaanxi Province,Yan’an 716000)
出处
《陕西医学杂志》
CAS
2020年第9期1175-1177,共3页
Shaanxi Medical Journal
关键词
男性
同性恋
艾滋病
人类免疫缺陷病毒
相关病原体
相关性
Men
Gay
Acquired immunodeficiency syndrome
Human immunodeficiency virus
Related pathogens
Correlation
