摘要
目的探讨尼莫地平联合前列地尔治疗动脉瘤性蛛网膜下腔出血(aSAH)后脑血管痉挛(CVS)的疗效。方法选取2012年1月至2016年1月我院aSAH后CVS的患者72例,随机分为两组。对照组患者36例,单纯给予尼莫地平治疗,观察组患者36例,给予尼莫地平联合前列地尔治疗。比较两组治疗前、治疗后1、2 w颅内主要动脉平均血液流速,统计两组预后情况及治疗过程中的不良反应发生率。结果两组治疗后2 w大脑前动脉、后动脉及中动脉的平均血流速度较治疗前、治疗后1 w显著降低(P<0.05),且观察组显著低于对照组(P<0.05)。观察组痊愈率高于对照组,死亡率低于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率无明显差异(P>0.05)。结论尼莫地平联合前列地尔对预防aSAH后CVS有较好的效果,有利于改善患者预后,且未增加用药不良反应,值得临床推广。
Objective To discuss the effect of nimodipine combined with alprostadil in the treatment of cerebral vasospasm （CVS） after aneurysms subarachnoid hemorrhage （aSAH）.Methods From January 2012 to January 2016,72 cases of patients with CVS after aSAH in our hospital were selected and divided into two groups randomly.The control group （n=36） were treated with nimodipine only,while the observation group （n=36） were treated with nimodipine combined with alprostadil.The artery mean blood flows in two groups before and 1week,2 weeks after treatment were compared,and the prognosis status and the incidence of adverse reactions in two groups during treatment were compared as well.Results The mean blood flow velocity of anterior cerebral artery,posterior cerebral artery and middle cerebral artery in two groups 2 weeks after treatment was lower than that before and 1 week after treatment （P〈0.05）,and the observation group was lower than that in the control group （P〈0.05）.The cure rate of observation group was higher than that of control group （P〈0.05）,and the mortality rate was lower than that of control group （P〈0.05）.There was no significant difference in the incidence of adverse reactions between the two groups （P〉0.05）.Conclusion Nimodipine combined with alprostadil has good effect on prevention of CVS after aSAH.It can improve the prognosis and will not increase the adverse drug reaction,therefore,it is worthy of clinical promotion.
出处
《锦州医科大学学报》
CAS
2017年第2期25-27,共3页
Journal of Jinzhou Medical University
