摘要
儿童是临床医疗面临的一个特殊群体,因年龄不同而致个体差异较大,临床用药需要个体化。近年来,群体药代动力学发展迅速,广泛应用于临床药学研究中,是实现个体化给药的有效途径。国内外针对一些治疗窗窄、个体差异化大的儿童用药进行了大量的群体药代动力学研究,为临床制定安全、合理的儿科给药方案提供了参考。
Children are a special group in clinical medical treatment. The significant individual differences require individualized administration of drugs. In recent years,the rapid development of population pharmacokinetics which are widely used in pharmaceutical research is an effective method to achieve individual administration. At home and abroad a large number of population pharmacokinetics are researched in chidren for drugs with narrow therapeutic window or in children with significant individual differences,which can provide information for the individualized dosing of drugs.
出处
《国际药学研究杂志》
CAS
CSCD
北大核心
2016年第3期445-449,共5页
Journal of International Pharmaceutical Research
关键词
群体药代动力学
儿童
个体化给药
非线性混合效应模型法
population pharmacokinetics
children
individual drug administration
nonlinear mixed effect model
