摘要
目的 :用非线性混合效应模型 (NONMEM)法估算门疹癫患者丙戊酸 (VPA)的相对清除率。方法 :5 6例门诊癫患者 po VPA达稳态 ,得到谷浓度数据 71点 ,用 FPIA法进行检测。采用 NONMEM法估算其清除率 (CL ) ,并定量考察体重、合并用药、VPA剂量对清除率的影响。结果 :按口服一房室开放模型得到 CL(L/ h)的最终回归方程为 :CL=(0 .0 0 896· WT+0 .0 919·L+0 .787· DCBZ)· (1+0 .2 96· m)。其中 WT为患者的体重 (kg) ;L 的值当体重小于 30 kg时为 1,其余为 0 ;DCBZ的值为卡马西平 (CBZ)按体表面积折算的日剂量 (g· m- 2 · d- 1 ) ;m的值当 VPA剂量大于 1.3g/ d时为 1,否则为 0。结论 :当VPA剂量 >1.3g/ d或合并使用 CBZ时 ,CL 增加 ,儿童 CL/ WT大于成人。
AIM:To estimate the relative clearance ( CL ) of valproic acid (VPA) in epileptic out patients. METHODS: Seventy one blood samples of VPA on steady state trough level were collected from 56 epileptic out patients, who have continuously administrated VPA for over 1 mo. All the samples were analyzed by flourescence polarization immunoassay (FPIA). The influence of body weight, VPA daily dose and carbamazepine (CBZ) on CL were investigated. RESULTS: One compartment open model with firs torder absorption and elimination was used to analyze the data. The final regression equation of CL (L/h) was: CL =( 0 008 96 ·WT+ 0 091 9 ·L+0 787·D CBZ )·(1+0 296·m), in which WT was the total body weight (kg), L=1 for WT<30 kg and 0 for others, D CBZ was the CBZ daily dose divided by body surface area (g·m -2 ·d -1 ), and m=1 for VPA daily dose >1 3 g and 0 for others. CONCLUSION: The clearance of VPA increases while co administrated with CBZ or the daily dose of VPA is over 1 3 g. The CL /WT of children is higher than that of adults.
出处
《中国临床药学杂志》
CAS
2000年第1期33-36,共4页
Chinese Journal of Clinical Pharmacy
关键词
丙戊酸
癫痫患者
血药浓度
监测
valproic acid
carbamazepine
epilepsy
population pharmacokinetics
flourescence polarization immunoassay
nonlinear mixed effect model
