摘要
儿童是临床医疗过程中的一个特殊群体,发育速度快、发育不成熟以及个体差异较大。近年来,儿童抗菌药物的不合理使用问题突出,利用药代动力学(pharmacokinetic,PK)/药效学(pharmacodynamic,PD)模型及抗菌药物PK/PD参数可为儿童抗菌药物使用提供依据,有助于儿童抗菌药物合理应用并优化临床个体化用药方案。
Children are the particular group during clinical treatments, with rapid and immature physical development and largely individual differences. In recent years, unreasonable usage of antibacterial drugs for children is a serious problem. The antimicrobials pharmacokinetic/pharmacodynamic(PK/PD) model and its parameters can provide evidence for antimicrobial use in children, which benefits for rational use of antibiotics in children and optimizies the clinical individualized drug delivery schemes.
作者
伏倩倩
祁媛媛
张晓波
FU Qianqian;QI Yuanyuan;ZHANG Xiaobo(Department of Respiration,Childrens's Hosptial of Fudan University,Shanghai 201102,China)
出处
《世界临床药物》
CAS
2022年第10期1262-1268,共7页
World Clinical Drug
关键词
药代动力学
药效学
抗菌药物
儿童
合理应用
pharmacokinetic
pharmacodynamic
antibacterial drug
pediatric
reasonable application
