摘要
目的探讨艾滋病病毒（HIV）急性期／早期感染者合并感染乙型肝炎病毒（HBV）的临床特点及实验室特征，进一步明确影响HIV／HBV重叠感染疾病进展的关键因素。方法采用回顾性分析的方法，了解单独HIV急性期／早期感染者（单独HIV感染组）和合并HBV的HIV急性期／早期感染者（HIv／HBV重叠感染组）的初始CD＋T淋巴细胞（简称CD,细胞）计数和病毒载量调定点，以及两组病人感染HIV一年内CD,细胞计数和HIV病毒载量的动态变化，和HIV急性期／早期合并HBV感染的临床特征。结果20例HIv／HBV重叠感染组的初始CD,细胞计数平均值为（443．55±197．00）个／止（213-985个／止），病毒载量调定点（4．34±0．99）Logl。拷贝／mL（1．82～5．47Log10拷贝／mL）。30例单独HIV感染组病人的初始CD4细胞计数平均值为（497．37±121．29）个／μL（196～792个／μL），病毒载量调定点（3．87±0．62）Log10拷贝／mL（2．77～5．19Loglo拷贝／mL）。HIv／HBV重叠感染组的初始CD4细胞计数明显低于单独HIV感染组，两组比较差异有统计学意义（P〈0．05）。HIv／HBV重叠感染组的病毒载量调定点明显高于单独HIV感染组，两组间差异有统计学意义（P〈0．05）。结论在我国HIV急性期／早期感染者中，HIV／HBV重叠感染者与单独HIV感染者比较，初始CD4细胞计数明显降低，病毒载量调定点明显升高，HIV病毒复制更为活跃。
Objective To explore clinical characteristics of HIV/HBV coinfection in acute/early HIV infection. Conclusion Retrospective method was used to investigate initial CD＋ T cell counts and HIV viral setpionts of acute/ early HIV infection, clinical characteristics of HIV/HBV Coinfection and dynamic changes of CD＋T counts and HIV viral loads of the two groups in one year. Results CD＋ T counts of 20 HIV/HBV coinfected patients were 443.55±197.00 cells/μL （range, 213±985 cells/μL） and their HIV viral setpoints were 4. 34±0. 99 Log10 copies/mL （range, 1.82±5. 47 copies/mL）. CD＋T counts of 30 acute/early HIV infected patients were（497.37±121.29） cells/μL （range, 196-792 cells/μL） and their HIV viral setpoints were （ 3. 87± 0. 62） Log10 copies/ml （ range, 2. 77 ± 5.19 Log10copies/mL）. CD4 cell counts were significantly lower and HIV viral loads were significantly higher in HIV/ HBV coinfected patients than those in acute/early HIV infected patients （both P〈 0. 05）. Conclusion In the stage of acute/early HIV infection, HBV coinfected patients have lower initial CD＋ T cell counts and higher HIV viral setpoints, suggesting active viral replication, compared with HIV only infected patients in China.
出处
《中国艾滋病性病》
CAS
2014年第4期233-236,共4页
Chinese Journal of Aids & STD
基金
国家"十二五"传染病重大专项资助项目(2012ZX10001001-008)
北京市中医药科技发展基金项目(JJ2009-31
JJ2011-05)
北京市中医管理局青年科学研究资助项目(QN2011-122011)
佑安肝病艾滋病基金(BJYAH-2011-023)~~
