摘要
目的探讨脉血康对不稳定型心绞痛(UAP)患者血小板活化状态因子的影响及临床疗效的观察。方法 80例UAP患者随即分为脉血康治疗组(简称脉血康组40例)和常规治疗组(简称常规组40例),2组病例在入院后次日凌晨分别空腹抽肘静脉血用流式细胞仪检测血清CD62p和GPⅡb/Ⅲa的水平;用散射比浊法测定血浆FIB-C的水平。选择健康体检者(对照组)和稳定型心绞痛(SAP组)患者各40例作对照,脉血康治疗8周后复查上述指标及评定临床疗效,并与对照组进行比较。结果 UAP组患者血清CD62p、GPⅡb/Ⅲa和血浆FIB-C较健康对照组明显增高(均P<0.01),较SAP组也明显增高(分别为P<0.05,P<0.01,P<0.01,P<0.05);脉血康治疗8周后CD62p、GPⅡb/Ⅲa和FIB-C均有显著降低(均P<0.01),较常规组对以上指标降低更明显(均P<0.05)。常规组治疗8周后总有效率达62.5%,而脉血康组总有效率达92.5%,2组比较差异有统计学意义(P<0.01)。结论脉血康可以抑制UAP患者血小板活化,有效控制心绞痛发作次数,有明显的抗凝血和抗血栓作用。
Objective To explore the effects of maixuekang（MXK）capsule on platelet activa- tion and its clinical efficacy in patients with unstable angina pectoris （UAP）. Methods Eighty patients with UAP were divided into MXK treatment group and conventional treatment group, with 40 patients in each group. On the next morning after admission to hospital, blood samples were obtained from cubital vein under fasting conditions to detect serum levels of CD62p and GP Ⅱ b/Ⅲ a and plasma levels of FIB-C by using flow cytometry and nephelometry,respectively. In addition,40 healthy subjects and 40 patients with stable angina pectoris （SAP） were selected as controls. After treatment for 8 weeks,levels of CD62p,GP Ⅱ b/Ⅲ a and FIB-C were reexamined and clinical effects were evaluated. Results Compared with UAP patients, CD62p, GP Ⅱ b/Ⅲa and FIB-C levels significantly decreased in healthy subjects and SAP patients （P〈0.05 or P〈 0.01）. After treatment with MXK capsule for 8 weeks,the levels of CD62p,GP ][ b/m a and FIB- C significantly decreased compared with the levels on admission（P〈0.01）. Furthermore, the lev- els in MXK capsule treatment group obviously decreased compared with conventional treatment group （P〈0.05）. The total effective rate in conventional treatment group was markedly lowerthan that in MXK treatment group （62.5 % vs 92. 5 % P 〈0.01）. Conclusion MXK capsule shows obvious anti-clotting and anti-thrombotic activities, and can inhibit platelet activity and control angina episodes in patients with UAP.
出处
《实用临床医学（江西）》
CAS
2012年第3期7-9,13,共4页
Practical Clinical Medicine
关键词
脉血康
不稳定型心绞痛
血小板活化
临床疗效
maixuekang capsule unstable angina pectoris platelet activation clinical efficacy
