摘要
目的探讨近现代名医治疗心绞痛的用药规律,为临床选方用药提供借鉴。方法整理《胸痹心痛古今名家验案全析》中近现代名医论治心绞痛的经验效方,将复方录入Excel 2010建立数据库,采用古今医案云平台(V2.3)进行频次分析、关联规则、聚类分析,采用SPSS Statistics 25.0进行因子分析。结果共纳入86位医家,254首经验方,涉及中药266味。高频药物有丹参、瓜蒌、薤白、甘草、半夏等。药性多用温,药味以苦、甘为主,归经以肺、心、脾为要,功效类别以补虚药、活血化瘀药等最为多见。关联规则获得“薤白-瓜蒌”“半夏-薤白”“半夏-瓜蒌”等11个核心药对。因子分析将药物分为6个公因子,涵盖瓜蒌薤白白酒汤、二陈汤、生脉散等方。聚类分析将药物分为4个组合,有健脾化痰、通阳散结、活血化瘀、益气敛阴之效。结论《胸痹心痛古今名家验案全析》中近现代医家治疗心绞痛的核心中药为丹参、瓜蒌、薤白、甘草、半夏等,以健脾化痰、通阳散结、活血化瘀、益气养阴为主要治法,临证可用二陈汤、瓜蒌薤白白酒汤、红花当归散、生脉散等方加减治疗。
Objective To explore the medication rules of modern famous doctors in treating angina pectoris,and to provide reference for selection of clinical prescription.Methods The empirical prescriptions used for angina pectoris by modern famous doctors in Xiongbi Xintong Gujin Mingjia Yanan Quanxi were sorted out,and the compound prescriptions were entered into excel 2010 to establish a database.The ancient and modern medical record cloud platform(V2.3)was used for frequency analysis,association rules and cluster analysis.SPSS Statistics 25.0 was used for factor analysis.Results A total of 254 empirical prescriptions of 86 doctors involving 266 kinds of Chinese medicine were included.High frequency drugs are Salvia miltiorrhiza,Trichosanthes kirilowii,Allium macrstemon,licorice,Pinellia ternata,etc.The drugs are mainly warm in nature,bitter and sweet in taste.The tropism of drugs is mostly lung,heart and spleen.The most commonly used used drugs among the efficacy categories are tonifying deficiency drugs,promoting blood circulation and removing blood stasis drugs.Eleven core drug pairs,such as Allium macrstemon-Trichosanthes kirilowii,Pinellia ternata-Allium macrstemon and Pinellia ternata-Trichosanthes kirilowii,were obtained by association rules.We classified the drugs into 6 common factors by factor analysis,including Gualou Xiebai Baijiu decoction,Shengmai san,Erchen decoction and so on.According to cluster analysis,the drugs were divided into four groups,which played the roles of invigorating spleen and resolving phlegm,dredging yang and dispersing stasis,promoting blood circulation and removing stasis,supplementing qi and astringing yin.Conclusion The core Chinese medicine for treating angina pectoris in Gujin Mingjia Yanan Quanxi is Salvia miltiorrhiza,Trichosanthes kirilowii,Allium macrstemon,licorice,Pinellia ternata.The main therapies for angina pectoris are:invigorating spleen and resolving phlegm,tong yang and loose knot,promoting blood circulation and removing blood stasis,replenishing qi and nourishing yin.
作者
俞赟丰
张紫怡
唐佩
周霞辉
张宜帆
简维雄
YU Yunfeng;ZHANG Ziyi;TANG Pei;ZHOU Xiahui;ZHANG Yifan;JIAN Weixiong(College of Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208 Hunan,China;The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007 Hunan,China;National Key Discipline of TCM Diagnositics,Hunan Provincial Key Laboratory,Hunan University of Chinese Medicine,Changsha 410208 Hunan,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2021年第9期1406-1411,共6页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金面上项目(81973753)
湖南省自然科学基金面上项目(2018JJ2291)
研究生质量工程项目(2018CX28,2020CX57)。
关键词
心绞痛
用药规律
关联规则
因子分析
聚类分析
Angina pectoris
medication rules
association rules
factor analysis
cluster analysis
