摘要
目的探讨奥曲肽对内镜逆行胰胆管造影（ＥＲＣＰ）术后高淀粉酶血症及胰腺炎的预防作用．方法行ＥＲＣＰ患者２７６例，随机分为两组：预防组１６７例，分别于术前３０ｍｉｎ及术后４ｈ内ｓｃ奥曲肽０１ｍｇ；对照组１０９例，ＥＲＣＰ术前后分别予生理盐水１ｍＬｓｃ．两组患者术前后均不用其他任何抑制胰腺分泌及预防胰腺炎药物．并分别于术前、术后２ｈ，２４ｈ作血清淀粉酶测定，同时观察胰腺炎的发生情况．结果预防组ＥＲＣＰ术后２ｈ，２４ｈ血淀粉酶（Ｕ／Ｌ）分别为２４６±２２４和２５２±２９１；明显低于对照组（４９９±５９７和４６６±５５９，Ｐ＜００１）；预防组发生胰腺炎７例（４２％），对照组发生９例（８３％，Ｐ＜００１）．
AIM To study the preventive effect of octreotide (sandostadin) on the hyperamylasemia and pancreatitis after endoscopic retrograde cholangiopanceatography(ERCP). METHODS ERCP patients (167) received either octreotide ( 0 1mg , SC, before and 4h after ERCP) or isotonic saline (109) as placebo. The mean concentration of serum amylase at 2 and 24h after ERCP was measured in all patients, and the abdominal pain and pancreatitis after ERCP were also observed in all patients. RESULTS The mean concentration of serum amylase (U/L) at 2 and 24h post was 246±224 and 252±291 in the preventive group, and 499±597 and 466±559 ( P <0 01) in the control group. Acute pancreatitis occurred in 9 cases (8 3%) of the control group and in 7 cases (4 2%) of preventive group after ERCP ( P <0 01) . The mean concentration of serum amylase and number of pancreatitis after ERCP were significantly lower in the preventive group than that in the control group ( P <0 01) . CONCLUSION Octreotide used pre and post ERCP can prevent effectively hyperamylasemia and acute pancreatitis after ERCP.
关键词
奥曲肽
胰腺炎
淀粉酶类
预防
octreotide/therapeutic use
cholangiopanceatography, endoscopic retrograde
pancreatitis/prevention and control
pancreatitis/blood
amylases/blood
