摘要
为了探讨急性胰腺炎早期发生休克的机理，寻找早期治疗急性胰腺炎的新途径。作者应用激光多普勒显微镜观察了急性胰腺炎大鼠肠系膜微循环的变化，并用血小板激活因子拮抗剂苦杏内酯Ｂ（ＢＮ５２０２１）进行治疗对比研究。将１８只ＳＤ大鼠分成胰腺炎组、治疗组及对照组。前两组动物用５％牛磺胆酸钠（１ｍｌ／ｋｇ）成功复制急性胰腺炎模型。治疗组在模型复制成功后５分钟和１８０分钟经颈静脉注射苦杏内酯Ｂ（１０ｍｇ／ｋｇ），其它两组以生理盐水代替注射，同时观察动物的存活时间。结果提示：急性胰腺炎的早期即有肠系膜微循环小动、静脉血流速度的明显减馒，小静脉的扩张。苦杏内酯Ｂ能有效抑制这些改变。治疗组动物平均存活时间较胰腺炎组延长近一倍。
o study shock in early acute pancereatitis (AP) ,we observed the change
of mesenterio-angial micreeir-culationin the rat with AP induced by sodium tauro-cholate infused
into the pancreatic duct. Meanwhile,the effect of platelet activating factor (PAF)
receptorantagonist BN52021 upon the animal with AP was alsoinvestigated. 18 Sprague-Dawlay
rats were divided in-to three groups: pancreatrtis group pan + BN52021group and control group.
pan + BN 52021 group wasinjected BN52021 (10mg/kg)intravenously 5 minutesand 180
minutes. after AP induction The other groupswere injected nomal sahne. We also studied the
sur-vival times of rats. The resuhs showed slow mesenteri-o-angial small arteriolar and venular
blcod flow velocityand dilated meseaterioangial small venular diameterduring the early phase
of AP. An protective effect ofBN 52021 on mesenterio-angial microcirculation
injuriesaccompanied by AP was confirmed Animals treatedwith BN 52021 survived 458. 3±9. 5
minutes whereasdeath occurred 243. 3± 2. 3 minutes after AP inductionin untreated rats (P<0.
01).
出处
《中华医学杂志》
CAS
CSCD
北大核心
1995年第3期139-140,共2页
National Medical Journal of China
关键词
胰腺炎
微循环
血小板激活因子
动物实验
病理
Pancreatitis Acute diseaseMicrocirculation Platelet activating factor Ani-mal
Labratory(Original arricle on page 139)
