摘要
目的探讨围手术期肝动脉栓塞化疗(TACE)预防大肝癌切除术后复发的作用。方法125例肝癌患者随机分为四组,分别在肝癌切除术前4～8周(A组,n=30)、术后2～4周(B组,n=32)和术后4～6周(C组,n=30)实施TACE治疗。将同期未进行TACE治疗的大肝癌手术切除患者作为对照组(D组,n=33)。结果A组术后1年复发率最高,B组最低(P<0.05);6个月复发率四组间差异显著(P<0.01),其中B组和A组、B组和D组、C组和A组差异显著;无严重手术并发症或TACE相关并发症。结论大肝癌切除术前TACE可能增加术后早期复发,不宜进行;术后2～4周早期实施TACE是预防大肝癌切除术后复发安全有效的方法。
Objective To investigate the preventive effect of transarterial chemcembolization(TACE) on recurrence of large hepatocellular carcinoma(HCC).Methods 125 patients with large HCC were randomized in to 4 groups.Of all the patients,30 in group A received TACE preoperatively,32 in group B under went in 2 to 4 weeks and 30 in group C were given TACE 4 to 6 weeks after hepatectomy.The postoperative recurring rate was determined and then compared with that of other 33 patients with large HCC who did not receive TACE operatively(group D).Results The 1-year recurring rate was significantly lower in group B than that in groups A and D(P<0.01 and 0.025).As for 6-month recurring rate,it was markedly lower in group B than that in groups A and D(P<0.01 and 0.025).Meanwhile,it was remarkably lower in group C than that in group A(P<0.01).However,there was no significant difference in 6-month recurring rate between group A and group D.Conclusions Treatment with preoperative TACE may increase the postoperative recurring rate.Performing TACE at early stage(2～4 weeks) after hepateetomy is safe and effective.Therefore,it can be an effective method for preventing the recurrence of HCC postoperatively.
出处
《中国基层医药》
CAS
2005年第6期651-652,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
肝动脉栓塞化疗
预防
肝癌
术后复发
Carcinoma,hepatocellular
Neoplasm recurrence,local
Therapeutic,chemoembolization
