摘要
目的:评价高复发因素原发性肝癌根治术后,选择性肝动脉化疗栓塞1、2年复发的价值。方法:1996年1月～2002年2月在本院行根治手术的原发性肝细胞癌60例,治疗组与对照组各30例,均有乙型肝炎、肝硬化病史。治疗组在根治术后2～4周行首次TACE,治疗间隔3～5个月,全部病例总计行126次治疗。全部病例在根治术后随访26～30个月。统计学分析采用χ2检验。结果:治疗组:1年内复发率6.7%(2/30),2年复发率16.7%(5/30);对照组:1年复发率30.0%(9/30),2年复发率53.3%(16/30)。统计学分析治疗组复发率低于对照组(P<0.05、P<0.01)。结论:选择性肝动脉化疗栓塞可显著降低高复发因素肝癌根治术后1、2年的复发率,治疗应维持到术后2年,以覆盖整个复发高峰期。
Objective： To evaluate the effect of postoperative TACE for preventing recurrence of hepatocellular carcinoma （HCC）. Methods： Sixty HCC patients underwent radical surgery between January 1996 and February 2002. Of the 60 cases, half received postoperative TACE （the treatment group） and the other half did not （the control group）. All patients had a history of hepatitis B and liver cirrhosis. TACE was conducted for the first time 2 to 4 weeks after surgery, with a treatment interval of 3 to 5 months. A total of 126 treatments were performed for all of the eases in the treatment group combined. The cases were followed up for 26 to 30 months after surgery. The chi-square test was applied for statistical analysis. Results： In the treatment group, the 1- and 2-year cumulative recurrence rate was 6.7% （2/30） and 16.7% （5/30）, respectively, while that in the control group was 30% and 53.3%, respectively. Statistical analysis showed that the relapse rate was lower in the treatment group than in the control group （P〈0.05, P〈0.01）. Conclusion： Selective transcatheter hepatic artery chemoembolization can effectively reduce the 1- and 2-year postoperative recurrence rate of liver cancer, and the treatment should be sustained for 2 years after the operation to cover the peak time of relapse.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2007年第8期454-456,共3页
Chinese Journal of Clinical Oncology
关键词
肝肿瘤/治疗
癌
肝细胞/外科学
化疗栓塞
治疗性
肿瘤复发
Tumor of liver Therapy Carcinoma Hepatocyte Surgery Chemoembolization Therapeutic Recurrence of tumor
