摘要
目的:介绍血管内皮细胞在剪切力的作用下发生了形态学的变化,可直接影响内皮细胞的生理功能,并与血栓形成等疾病有一定关系。资料来源:应用计算机检索Medline1993-01/2004-01期间的关于剪切力的相关文章,检索词:“Deformability”和“endothelialcell”,限定文章语种类为英文;检索维普数据库1995-01/2004-01期间剪切力相关文章,检索词“剪切力”、“内皮细胞”和“细胞骨架”,限定语言种类为中文。资料选择:选择剪切力、血管内皮细胞、细胞骨架蛋白血液流变学的相关文献38篇。资料提炼:在38篇文献中,按剪切力与血管内皮细胞相关性研究的新观点进行提炼,对文献进行分类整理,用于综述,其中10篇选用为参考文献。资料综合:剪切力可使血管内皮细胞发生形态学改变。而这种变化影响细胞损伤后的再生。同时剪切力可改变内皮细胞生理功能,激活内皮细胞Ca2+通道、K通道,引起力化学信号转导。+结论:剪切力通过力化学信号转导途径,实现力化学转换,从而调节细胞的生理功能。这一生理功能改变可引起机体某些病理变化,最终导致血栓形成,从生物物理学观点阐明了剪切力与血栓形成的关系。
OBJECTIVE: The association of psychosocial factors with various medical clinical diseases has attracted more and more attentions. Based on this reality, there is a tendency of lightening the diagnosis of psychosomatic diseases gradually in recent years, and it has been replaced by consideration of clinical diseases from the psychological and physical aspects. Comorbidity of cardiovascular disease (CVD) and depression is a problem to be investigated.DATA SOURCES: An online search of Medline database was undertaken by using the keywords of “ cardiovascular disease, depression' to identify the relevant articles about depression and CVD published in English from January 2002 to December 2004. Meanwhile, Wanfang database was scanned manually to search relevant articles published from January 2002 to December 2004, the keywords were “ cardiovascular disease, depression' with language limited to Chinese.STUDY SELECTION: After the above search, the articles about the psychological problems, psychosomatic disease and comorbid disorders in CVD were collected, including articles of comparative study and survey analysis, and the repetitive papers and reviews were excluded.DATA EXTRACTION: Forty articles were collected, and 23 of them were in accordance with the inclusion criteria, 8 repetitive ones were excluded, and 9 were reviews. Eight articles served as the important reference data.DATA SYNTHESIS: Comorbidity of depression and somatic diseases was very common, especially with many chronic diseases. CVD and depression were the cause and effect of each other, which was more obvious in females. Cardiological physicians should pay attention to differentiating the clinical manifestations caused by comorbidity in clinical diagnosis, and take notice of the affective disorders induced by drugs during the treatment of CVD. CONCLUSION: CVD is closely related with depression, so sufficient recognition and attention should be attached to the differentiation during clinical diagnosis and treatment, and diagnostic and therapeutic
出处
《中国临床康复》
CSCD
北大核心
2005年第11期146-147,共2页
Chinese Journal of Clinical Rehabilitation
